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1 Acta Chromatographica

1 2002

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Gas chromatographic determination of residual acridine and iminodibenzyl in dibenzazepine drugs and related compounds

Syed A. A., Silwadi M. F., Kirumakki S. R., Narasimiah N.

Acta Chromatographica

2002

No. 12

80-88

A new, selective, packed-column gas-chromatographic method has been developed for the determination of acridine in the presence of imino-dibenzyl and iminostilbene. The method involves dissolution of acridine and iminodibenzyl or iminostilbene in benzyl alcohol and injection of this solution into a 2 m × 2 mm i.d. glass column packed with 4% OV-225 on 80-100 mesh Chromosorb WAW-DMCS. Under these conditions acridine, iminodibenzyl, and iminostilbene are eluted after 2.37, 3.49, and 4.76 min, respectively. The method is reproducible and the relative standard deviation for 10 repeated injections of 2 žL is <2%. The procedure has been success-fully employed for the determination of the amounts of iminodibenzyl residues in trimipramine maleate, imipramine hydrochloride, clomipramine hydrochloride, and opipramol formulations and in samples of these compounds subjected to forced degradation.