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2 International Letters of Chemistry, Physics and Astronomy

2 2014

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Synthesis, characterization and biological evaluation of 2,5-di-substituted 1,3,4-oxadiazole derivatives

Makwana H., Naliapara Y. T.

International Letters of Chemistry, Physics and Astronomy

2014

Vol. 15

48--54

We have reported some novel 1,3,4-oxadiazole synthesized by conventional method .The reaction of 5-bromothiophene-2-carbohydrazide and different benzoic acid derivatives reflux in toluene using phosphorus oxychloride as a catalyst, yielded a series of 2,5-di-substituted 1,3,4-oxadiazole HM-2a to HM-2t. The newly synthesized 2,5-di-substituted 1,3,4-oxadiazole were purified by column chromatography and characterized by IR, Mass, 1H NMR, 13C NMR spectroscopy and elemental analysis. All synthesized compounds were screened for antimicrobial activity using cup plate method. All the compounds showed moderate to good antimicrobial activity and anti fungal activity.

Synthesis, characterization and antimicrobial activity of N’-benzylidene-5-bromothiophene-2-carbohydrazide derivatives

Makwana H., Naliapara Y. T.

International Letters of Chemistry, Physics and Astronomy

2014

Vol. 14, iss. 1

99--105

Some new N’-benzylidene-5-bromothiophene-2-carbohydrazide derivatives possessing thiophene nucleus were synthesized and characterized by IR, NMR and mass spectral analysis. All synthesized compounds were screened for antimicrobial activity using cup plate method. All the compounds showed moderate to good antimicrobial activity and anti fungal activity.