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2 International Letters of Chemistry, Physics and Astronomy

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Antibacterial, antifungal, anti-oxidant, anti-inflammatory and anti-hypertensive activities of N-chloropyrazinamide

Vaijayanthi S. P., Mathiyalagan N.

International Letters of Chemistry, Physics and Astronomy

2014

Vol. 7

1--8

N-chloropyrazinamide was prepared by the chlorination of pyrazinamide using trichloroisocyanuric acid. The experimental results ascertained that the tested N-chloropyrazinamide showed good antimicrobial activities when compared to standard drug. It was found that N-chloropyrazinamide at different concentrations exhibited significant dose dependent anti-oxidant, anti-inflammatory and anti-hypertensive activity.

Kinetics of oxidation of amino acids by a newly synthesized oxidant, N-chloropyrazinamide in aqueous acetic acid medium

Vaijayanthi S.P., Mathiyalagan N.

International Letters of Chemistry, Physics and Astronomy

2013

Vol. 11

1--8

The kinetics of oxidation of amino acids namely, alanine, glycine, leucine, phenyl alanine and valine by N-chloropyrazinamide (NCPZA) in aqueous acetic acid medium in the presence of hydrochloric acid have been investigated. The observed rate of oxidation is first order in [NCPZA], [H+] and [Clˉ]. The order with respect to [amino acid] is zero. The rate of oxidation increases with increase in the percentage of acetic acid. The reaction rate increases slightly with increase in ionic strength, while retards with addition of pyrazinamide. Arrhenius and thermodynamic activation parameters have been evaluated from Arrhenius plot by studying the reaction at different temperatures. A most probable reaction mechanism has been proposed and an appropriate rate law is deduced to account for the observed kinetic data.