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1 2021

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Analysis of the antibacterial properties of polycaprolactone modified with graphene, bioglass and zinc-doped bioglas

Hajduga Maciej B., Bobiński Rafał, Dutka Mieczysław, Ulman-Włodarz Izabela, Bujok Jan, Pająk Celina, Ćwiertnia Michał, Kurowska Anna, Dziadek Michał, Rajzer Izabella

Acta of Bioengineering and Biomechanics

2021

Vol. 23, no. 2

131--138

Purpose: Innovative biomedical filaments for 3D printing in the form of short and biodegradable composite sticks modified with various additives were used to prepare biomaterials for further nasal implants. As the respiratory tract is considered to be potentially exposed to contamination during the implantation procedure there is a need to modify the implant with an antibacterial additives. The purpose of this work was to analyze the effect of biodegradable polymer – polycaprolactone (PCL) modification with various additives on its antibacterial properties. Methods: PCL filament modified with graphene (0.5, 5, 10% wt.), bioglass (0.4% wt.) and zinc-doped bioglass (0.4% wt.) were used to print spatial biomaterials using FDM 3D printer. Pure polymer biomaterials without additives were used as reference samples. The key task was to assess the antimicrobial impact of the prepared biomaterials against the following microorganisms: Staphylococcus aureus ATCC 25293, Escherichia coli ATCC 25922, Candida albicans ATCC 10231. Results: The research results point to a significant antibacterial efficacy of the tested materials against S. aureus and C. albicans, which, however, seems to decrease with increasing graphene content in the filaments. A complete lack of antibacterial efficacy against E. coli was determined. Conclusions: The tested biomaterials have important antibacterial properties, especially against C. albicans. The obtained results showed that biomaterials made of modified filaments can be successfully used in implantology, where a need to create temporary tissue scaffolds occurs.