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Study on reliability of emergency braking performance of high-speed and heavy-load monorail crane

Zhang Jiarong, Lu Hao, Jiang Hui, Miao Yun, Shi Zhiyuan

Eksploatacja i Niezawodność

2024

Vol. 26, no. 1

art. no. 174820

The reliability of monorail crane braking system has an important influence on thebraking safety. The high speed and heavy load operation poses a great challenge to the braking safety,and it is necessary to evaluate its braking reliability accurately and efficiently. Firstly, the dynamic performance and thermal-mechanical coupling characteristics of high-speed and heavy-loadmonorail crane under different braking parameters were analyzed. Secondly, the random response model of braking distance and braking temperature was established by combining the design of experiment method (DoE) and Dendrite Net (DD). Finally, the high-order momentsaddlepoint approximation (SPA) method was used to evaluate the emergency braking reliability of the monorail crane. Theresultscan provide a reference for the selection of key parameters and the evaluation of braking safety of the monorail crane braking system under high-speed and heavy-load conditions.

Determination of sarecycline by UPLC-MS/MS and its application to pharmacokinetic study in rats

Shen Yonghui, Meng Deru, Chen Feifei, Jiang Hui, Liming Hu, Zhou Yunfang, Zhang Miaomiao

Acta Chromatographica

2021

Vol. 33, no. 3

228--233

Sarecycline is a narrow-spectrum antibiotic for the treatment of acne, which is a chronic inflammatory disease of the hair follicle sebaceous glands. In the study, UPLC-MS/MS was used to establish a rapid and accurate analytical method. The sarecycline was determined with poziotinib as internal standard (IS) in rat plasma. An ACQUITY UPLC HSS T3 column (2.1 × 100 mm, 1.8 μm) could performe chromatographic separation with the mobile phase (methanol: water of 0.1% formic acid) with gradient elution. The ions of target fragment were m/z 488.19→410.14 for sarecycline and m/z 492.06→354.55 for poziotinib, which could quantify the electrospray ionization of positive multiple reaction monitoring (MRM) mode. The linear calibration curve of the concentration range was 1–1,000 ng/mL for sarecycline with a lower limit of quantification (LLOQ) of 1 ng/mL. The mean recovery was between 82.46 and 95.85% for sarecycline and poziotinib in rat plasma. RSD for precision of inter-day and intra-day were between 3.24 and 13.36%, and the accuracy ranged from 105.26 to 109.75%. The developed and validated method was perfectly used in the pharmacokinetic study and bioavailability of sarecycline after intravenous and oral administration in rats.