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1
Content available remote Synthesis of some New Quinoxalines Bearing Pyridinyl Thiazole Moiety
Kathrotiya H. G., Naliapara Y. T.
International Letters of Chemistry, Physics and Astronomy
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2015
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Vol. 52
74--83
EN
Keeping the objective to build up a new structural class of quinoxaline, a new series of quinoxaline derivatives bearing the pyridinyl thiazole nucleus have been synthesized by base-catalyzed chloro-amine condensation reaction approach. The protocol offers expeditious and easy synthesis with excellent yield. The chemical structures of the synthesized compounds were elucidated by 1H NMR, 13C NMR, FT-IR, elemental analysis, and mass spectral data.
2
Content available remote Synthesis of Novel Triazolo[4,3-a]Quinoxaline Darivatives Containing Pyridinyl and Thiazole Nucleous
Kathrotiya H. G., Naliapara Y. T.
International Letters of Chemistry, Physics and Astronomy
|
2015
|
Vol. 52
63--73
EN
On pursuing research about [1,2,4] triazolo [4,3-a] quinoxaline, in this paper we report a small library of novel class of [1,2,4] triazolo [4,3-a] quinoxaline derivatives containing pyridinyl thiazole moiety. Particularly valuable features of this method include high yield, broad substrate scope, shorter reaction time and straightforward procedure. The structures of new compounds have been characterized on the basis of elemental analysis, FT-IR, 1H NMR, 13C NMR, and mass spectral data.
3
Content available Simple and Efficient Three Component One-pot Synthesis of Pyrazolo[1,5,a]pyrimidines
Morabia A. R., Naliapara Y. T.
International Letters of Chemistry, Physics and Astronomy
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2015
|
Vol. 41
73--81
EN
A series of novel 5-(2-bromophenyl)-N-cyclohexyl-2-(methylthio)-6-nitro-7-phenyl-4,7-dihydropyrazolo[1,5-a]pyrimidine-3-carboxamides were synthesized by a one-pot reaction of 5-amino-N-cyclohexyl-3-(methylthio)-1H-pyrazole-4-carboxamide, 1-(2-bromophenyl)-2-nitroethanone and aryl aldehydes in the presence of boric acid in water at refluxing temperature. Structures of compounds were demonstrated by Fourier transform infrared, 1H NMR, 13C NMR and elemental analysis. The advantages of this method are mild reaction condition, good yields, and operational simplicity.
4
Content available Two Step One-Pot Synthesis of Novel 5-(4-Fluorophenyl)-1H-Beno[e][1,4]Diazepin-2(3H)-One and it’s Base Catalyzed Transformation to N-Alkyl and C-3 Arylidene Derivatives
Patel Anil S., Khunt H. R., Ghelani S. M., Babariya J. S., Vilapara K. V., Naliapara Y. T.
International Letters of Chemistry, Physics and Astronomy
|
2014
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Vol. 11, iss. 2
106-115
EN
We have demonstrated two step one-pot synthesis of novel 5-(4-Fluorophenyl)-1H-Beno[e][1,4]Diazepin-2(3H)-one using 2-Amino-4’-fluorobenzophenone as initial stating material. The small library of N-alkylation and C-3 benzylidene derivatives have been synthesized by base catalyzedreaction of 5-(4-fluorophenyl)-1H-benzo[e][1,4]diazepin-2(3H)-one (3) nucleus with various alkyl halides and aromatic aldehydes respectively.
5
Content available Synthesis, characterization and biological evaluation of 2,5-di-substituted 1,3,4-oxadiazole derivatives
Makwana H., Naliapara Y. T.
International Letters of Chemistry, Physics and Astronomy
|
2014
|
Vol. 15
48--54
EN
We have reported some novel 1,3,4-oxadiazole synthesized by conventional method .The reaction of 5-bromothiophene-2-carbohydrazide and different benzoic acid derivatives reflux in toluene using phosphorus oxychloride as a catalyst, yielded a series of 2,5-di-substituted 1,3,4-oxadiazole HM-2a to HM-2t. The newly synthesized 2,5-di-substituted 1,3,4-oxadiazole were purified by column chromatography and characterized by IR, Mass, 1H NMR, 13C NMR spectroscopy and elemental analysis. All synthesized compounds were screened for antimicrobial activity using cup plate method. All the compounds showed moderate to good antimicrobial activity and anti fungal activity.
6
Content available Synthesis, characterization and antimicrobial activity of N’-benzylidene-5-bromothiophene-2-carbohydrazide derivatives
Makwana H., Naliapara Y. T.
International Letters of Chemistry, Physics and Astronomy
|
2014
|
Vol. 14, iss. 1
99--105
EN
Some new N’-benzylidene-5-bromothiophene-2-carbohydrazide derivatives possessing thiophene nucleus were synthesized and characterized by IR, NMR and mass spectral analysis. All synthesized compounds were screened for antimicrobial activity using cup plate method. All the compounds showed moderate to good antimicrobial activity and anti fungal activity.
7
Content available Synthesis and Characterization of Novel (E)-1-(aylideneamino)-6-(4-methoxyphenyl)-2-oxo-4-(trifluoromethyl)-1,2-dihydropyridine-3-carbonitrile derivatives
Khunt H. R., Babariya J. S., Dedakiya C. D., Maniar C. A., Naliapara Y. T.
International Letters of Chemistry, Physics and Astronomy
|
2014
|
Vol. 11, iss. 3
185--192
EN
We have described simple facile method for the synthesis of Novel (E)-1-(aylideneamino)-6-(4-methoxyphenyl)-2-oxo-4-(trifluoromethyl)-1,2-dihydropyridine-3-carbonitrile derivatives by using 1,3-diketone as synthon. All the synthesized compounds were characterized by IR, Mass and 1H NMR spectroscopy.
8
Content available Synthesis and characterization of fully substituted pyrimidines by using ketene dithioacetal as potent antimicrobial agent
Khunt H. R., Pipaliya P. P., Ghelani S. M., Babariya J. S., Naliapara Y. T.
International Letters of Chemistry, Physics and Astronomy
|
2014
|
Vol. 5
134--141
EN
Various ketene dithioacetals of acetoacetanilides were reacted with guanidine nitrate in the presence of base to produce the 2-amino-4-isopropyl-6-alkoxy-N-arylpyrimidine-5-carboxamide derivatives with good yields. All the synthesized compounds were characterized by mass, NMR and IR and also evaluated for antimicrobial activity against five different bacterial and fungal strains. The compounds 4i, 4k and 4l has found comparatively good active against all the bacterial strains.
9
Content available Synthesis and antimicrobal activities of some novel triazolo[1,5-a]pyrimidine derivatives
Gami S. P., Vilapara K. V., Khunt H. R., Babariya J. S., Naliapara Y. T.
International Letters of Chemistry, Physics and Astronomy
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2014
|
Vol. 11, iss. 2
127-134
EN
A convenient synthesis of substituted 1,2,4-triazolo[1,5-a]pyrimidine was carried out by the reaction of various ketene dithioacetals with 5-amino 1,2,4-triazole in methanol in presence of sodium methoxide. The newly synthesized compound were characterized by 1H NMR, 13C NMR, IR, MS, elemental analysis and screened for their antimicrobial activity against various strains of bacteria and fungi.
10
Content available One pot multi component synthetic approach towards the formation of 1,2,4-triazolo[1,5-a]pyrimidine analogues and their biological evaluation
Khunt H. R., Pipaliya P. P., Ghelani S. M., Babariya J. S., Naliapara Y. T.
International Letters of Chemistry, Physics and Astronomy
|
2014
|
Vol. 12
20--25
EN
A library of functionalised 1,2,3-triazolo[1,5-a]pryrimidine derivatives has been synthesized by one pot multicomponenet reaction. All synthesized novel compounds were characterised by 1H NMR, IR, mass and elemental analysis. Compounds were also screened against bacterial and fungle strain.
11
Content available An efficient solid phase one port synthesis of Novel triazolo[1,5-a]pyrimidine derivatives from 4-(4-aminophenyl)morpholin-3-one and evaluation of their antimicrobial activity
Prajapati D. R., Vilapara K. V., Naliapara Y. T.
International Letters of Chemistry, Physics and Astronomy
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2014
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Vol. 14, iss. 1
12--21
EN
A series of novel triazolo[1,5-a]pyrimidine derivatives was synthesized from 5-amino-1,2,4-triazole and biologically active morpholinone amine in excellent yield as promising class of antimicrobial agents. The antimicrobial activities were investigated against Escherichia coli, Staphylococcus aureus, Pseudomonas aeruginosa, Staphylococcus pyogen, Candida albicans, Aspergillusniger, Aspergillusclavatus and compared with standard drugs Ampicillin, Chloramphenicol, Norfloxacin and Griseofulvin. All the synthesized compounds were characterized by IR, 1H NMR, 13C and mass spectroscopy. The result of antimicrobial activity data revealed that compound 4f,4g and 4i were found more active against bacterial species and compound 4c, 4d, 4g, 4i and 4jwere found more active against fungal strain, while other compounds shows moderate to law activity against microbes.
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