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1 2004

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The Application of Magnesium Ion Selective Electrode in Clinical Analysis

Malon A., Brockmann Ch., Fijalkowska-Morawska J., Rob P., Maj-Zurawska M.

Polish Journal of Chemistry

2004

Vol. 78 / nr 9

1619-1625

The role of magnesium is primarily that of a cofactor in intracellular biochemical reactions, therefore, the concentration of intracellular ionized magnesium is much more physiologically relevant. The determination of the ionized magnesium (iMge) in erythrocytes by ion-selective electrode for routine clinical measurements was first time investigated. Intracellular and extracellular magnesium concentration in critically ill postoperative patients and in dialyzed patients was compared with healthy individuals. Of the investigated parameters, iMge seems to be the best magnesium parameter to observe hypo- or hypermagnesemia for both groups of patients. The correlation that was found between extracellular and intracellular magnesium concentrations can be also used to evaluate the magnesium status.