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Study on in vitro toxicity of biometal(II) Monensinates against rat Zajdela liver tumour

Alexandrova Radostina, Zhivkova Tanya, Ivanov Dimitar, Andonova-Lilova Boika, Dyakova Lora, Pantcheva Ivayla, Dorkov Peter

Chemistry-Didactics-Ecology-Metrology

2020

R. 25, NR 1-2

125--132

The ability of Monensic acid A (MonH∙H2O) and its neutral metal complexes [M(Mon)2(H2O)2]with ions of Mg2+, Ca2+, Mn2+, Co2+, Ni2+ and Zn2+ to decrease viability and proliferation of primary cell cultures, originating from a chemically induced transplantable liver tumour of Zajdela in rats, and bone marrow cells from the same tumour-bearers, was evaluated. Experimental data revealed that manganese(II) and nickel(II) complexes of Monensin A are relatively more selective against the tumour as compared to the healthy bone marrow cells.