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Wpływ parametrów powietrza wlotowego na zapotrzebowanie mocy sieci sprężonego powietrza w przemyśle spożywczym

Perz K., Rewolińska A., Suchy D.

Inżynieria i Aparatura Chemiczna

2015

Nr 5

271--272

Celem badań była ocena energochłonności i ekonomii pracy osuszaczy ziębniczych firmy Hiross oraz projektu pracowników Politechniki Poznańskiej (z rekuperacją i bez niej) przy porównywalnych parametrach powietrza sprężonego. Najniższe zużycie mocy osiągał osuszacz PP z rekuperacją. Osuszacz PP bez rekuperacji i osuszacz Hiross wykazywały prawie takie samo zużycie mocy dla powietrza o temperaturze wejściowej ok. 12°C.

The assessment of energy consumption and economy of refrigerant dryers: one of Hiross company and two designed by employees of Poznań University of Technology (with and without recuperation) having comparable compressed air parameters were studied. The lowest power consumption was reached by the PP dryer with recuperation. The PP dryer without heat recovery and the Hiross air drier showed almost the same power consumption for air inlet temperature of approx. 12°C.

RP-HPLC-UV Determination of ezetimibe in serum: Method development, validation and application to patients chronically receiving the drug

Suchy D., Łabuzek K., Pierzchała O., Okopień B.

Acta Chromatographica

2013

Vol. 25, no. 3

483--502

Ezetimibe is the first in a new class of antihypercholesterolemic drugs. Since it has not long been available on the market, many of its properties may still be revealed. Analytical methods for its determination are scarce, especially regarding serum samples. A simple, fast, and effective high-performance liquid chromatography-ultraviolet (HPLC-UV) method for the determination of ezetimibe concentration in human serum has therefore been developed. Three mobile phases were analysed, and original modifications to the concentration and flow parameters were made. Of five potential internal standards (IS), only nitrendipine was found to be suitable. The analytical wavelength was chosen based on the absorption spectrum of ezetimibe in the mobile phase. Finally, an extraction analysis was performed using two different solvents, and the extrahent volume was optimised. The final method developed was as follows. Single extraction of 1 mL serum sample, spiked with IS, was performed using 10 mL of methyl-t-butyl ether. Separation was obtained at ambient temperature on a Waters C18 Symmetry Shield (4.6 mm × 250 mm, 5 μm) column. The isocratic mobile phase was composed of acetonitrile and 0.1 M ammonium acetate aqueous solution 55:45 (v/v), set at flow rate of 0.75 mL min−1. Ezetimibe was detected at a wavelength of 232 nm after 5.49 min, and the IS was detected at 8.05 min. The developed method has been validated according to ICH standards. It was found to be specific, precise, accurate and linear over the range 10-800 ng mL -1 with R2 > 0.998, and detection and quantification limits of 4.60 ng mL -1 and 13.94 ng mL -1, respectively. The method has been applied to clinical serum samples. The developed technique allowed for successful in vivo assessment of ezetimibe concentrations in samples obtained from hypercholesterolemia patients who are chronically receiving the drug.