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3 Polish Journal of Chemistry

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Butyrylcholinesterase Inhibitory C-Glycoside from Symplocos racemosa

Ahmad V., Zubair M., Abbasi M., Kousar F., Rasheed M., Rasool N., Hussain J., Nawaz S., Choudhary M.

Polish Journal of Chemistry

2006

Vol. 80, nr 3

403-407

The re-investigation of the chemical constituents of Symplocos racemosa Roxb. led to the isolation of one new C-glycoside, symcososide (1) along with one known compound beta-sito-glycoside (2). The structure of the new compound was determined by 1D and 2Dhomonuclear and heteronuclearNMRspectroscopy, chemical evidences, and by comparison with the published data of the closely related compounds. The glycoside 1 displayed in vitro inhibitory activity against butyrylcholinesterase (BChE) enzyme with IC50 value of 21.2 š 0.01 miM.

Tanacetamide C : One New Ceramide from Tanacetum artemisioides

Hussain J., Ahmad V., Hussain H, Hassan Z., Khan A., Farooq U

Polish Journal of Chemistry

2005

Vol. 79 / nr 6

967-971

A reinvestigation with a modified extraction procedure of Tanacetum artemisioides resulted in the isolation and structure elucidation of one new ceramide named tanacetamide C and assigned structure 2R,3'R,3R,4'S,6R,4E-N-[3',4'-dihydroxydodecanoyl]- 2-amino-4-nonacosene-1,3,6-triol (1). In addition 5,4'-dihydroxy-3,6,7-trimethoxyflavone (2), 5-hydroxy-3,6,7,4'-tetramethoxy flavone (3), leukodin (4) were also isolated for the first time from this species. The structure elucidation of the isolated new compound was based primarily on 1D and 2D NMR analysis, including COSY, HMQC, HMBC correlations.

Three New Diterpenoids from Euphorbia decipiens

Ahmad V., Hussain H, Jassbi A. R., Zahid M., Hussain J., Bukhari I. A., Yasin A., Choudhary M. I

Polish Journal of Chemistry

2002

Vol. 76 / nr 12

1699-1706

Three new diterpene esters with a tricyclic myrsinol-type skeleton have been isolated from Euphorbia decipiens Boiss.&Buhse. The structure elucidation of the isolated compounds was based primarily on 1D and 2D-NMR analysis, including COSY, HMQC, HMBC and NOESY correlations. The compound 1 showed inhibitory activity against prolyl endopeptidase and compound 2 showed analgesic activity.