Wyniki wyszukiwania - BazTech

1

Role of the hydrophobic core in cytoskeleton protein: cardiac myosin binding protein C

Gołda M., Banach M., Wiśniowski Z., Ziajka W., Roterman I.

Bio-Algorithms and Med-Systems

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2017

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Vol. 13, no. 3

161--165

EN

Cardiac myosin binding protein C is the object of analysis presented in this paper. The fuzzy oil drop model was applied to analyze the status of the hydrophobic core in two forms of this protein: WT and R502W mutant. The status of the mutant is revealed to be of lower stability than the WT form. The high order of the hydrophobic core is interpreted as the factor of stability of the tertiary structure. The muscle proteins, which undergo significant structural changes as the consequence of external stretching forces, are expected to return to initial structures after the release of an external force. The mutant R502W appears to represent lower stability; thus, the return to the initial structure may be of lower probability. The comparable analysis to other muscle domains (titin) and immunoglobulin domains suggests the very subtle relation to the biological activity of these proteins.

2

Simulations in orthopedics and rehabilitation - Part 2: Computer simulations

Dygut J., Piwowar P., Gołda M., Popławski K., Jakubas R., Gonzales G., Piwowar M.

Bio-Algorithms and Med-Systems

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2016

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Vol. 12, no. 4

159--168

EN

Simulations in medicine have already become the mainstream trend in the field of research and education. It includes simulations on simulators through which students are afforded the opportunity to train manual skills as well as series of simulations that enable one to train not just motor and manual skills alone. Some of these offer the student the basis to train decision-making process and conduct experiments that visualize biological phenomena that are important from a doctor’s perspective. The authors have done a review of medical computer simulations and found that simulations in medicine focus, in respect of the issues raised, on techniques and computer science aspects. The first one is discussed in the paper “Simulations in orthopedics and rehabilitation – Part I: Simulators.” The second one is discussed in this paper. In the paper, the authors focus on computer simulations, in the broadest sense, presenting them while taking into consideration the distinction between simulations used for the following purposes: test (conducted under laboratory conditions), training (incorporated into school, universities syllabus), and diagnostic and therapeutic (within the hospital, clinics, private medical practice).

3

Simulations in orthopedics and rehabilitation - Part 1: Simulators

Dygut J., Piwowar P., Gołda M., Popławski K., Jakubas R., Gonzales G., Piwowar M.

Bio-Algorithms and Med-Systems

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2016

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Vol. 12, no. 4

147--157

EN

Nowadays, medical simulators and computer simulation programs are used to train various skills required in medicine. The development of medicine, including orthopedics and rehabilitation, has meant that resident physicians, within a much shorter period of time, must acquire the knowledge and skills that their older colleagues gained over years, learning as they operated on patients. For this reason, simulation very often helps the doctor and others engaged in health care train some techniques necessary during the work before they start working in a clinical environment. They have a chance of fine-tuning certain skills under nonclinical environment. On the other hand, simulation techniques are used in medical scientific research to know and explain the different biological processes that can be used for better patient treatment in the future. In this paper (Part I), the authors focused on the presentation of different types of simulators for the following purposes: test (conducted under laboratory conditions), training (incorporated into school, universities syllabus), diagnostic and therapeutic (within the hospital, clinics, private medical practice).

4

Wielowarstwowa uniwersalna powłoka ochronno-terapeutyczna na implanty – kontrolowane uwalnianie leku z parylenu C modyfikowanego plazmą tlenową

Gołda M., Gębarowska K., Musiał-Kulik M., Kasperczyk J., Kotarba A.

Engineering of Biomaterials

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2013

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Vol. 16, no. 122-123 spec. iss.

36--39

PL

Opracowano wielowarstwową ochronną powłokę polimerową na bazie parylenu C, którą modyfikowano plazmą tlenową. Przeprowadzono badania składu chemicznego powierzchni (XPS) i Swobodnej Energii Powierzchniowej (kąt zwilżania, metoda Owensa-Wendta) próbek modyfikowanego parylenu C. Otrzymano matryce z bioresorbowalnego kopolimeru L-laktydo-ko-glikolidu (PLGA) zawierające cząsteczki modelowego leku przeciwzapalnego (ibuprofen), następnie matryce poddano degradacji hydrolitycznej oraz ocenie profilu uwalniania substancji leczniczej. Zmiany zachodzące w mikrostrukturze łańcucha kopolimerowego obserwowano przy wykorzystaniu wysokorozdzielczej spektroskopii magnetycznego rezonansu jądrowego (NMR), natomiast kinetykę uwalniania leku z matryc badano metodą wysokosprawnej chromatografii cieczowej (HPLC).

EN

The multilayer protective polymer coating based on parylene C modified with oxygen plasma was developed. The paper reports an investigation on surface chemical composition (XPS) and surface free energy (contact angle, Owens-Wendt) of modified parylene C. Bioresorbable L-lactide-co-glycolide copolymer (PLGA) was used to obtain drug-loaded matrices. The matrices underwent hydrolytic degradation and estimation of drug release profile. The microstructural changes which appeared during degradation were observed by means of high resolution nuclear magnetic spectroscopy (NMR). The kinetic profiles of drug release were investigated with high performance liquid chromatography (HPLC).

5

Powłoki parylenowe do ochrony powierzchni metalowych implantów

Cieślik M., Gołda M., Kotarba A.

Engineering of Biomaterials

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2012

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Vol. 15, no. 116-117 spec. iss.

39--41

6

Generowanie nanoporów w polimerowej warstwie zabezpieczającej powierzchnie implantów metalowych w kierunku kontrolowanego uwalniania leków

Gołda M., Kotarba A.

Engineering of Biomaterials

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2012

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Vol. 15, no. 116-117 spec. iss.

19--21

PL

W pracy przedstawiono badania składu chemicznego i morfologii próbek parylenu C modyfikowanego przy użyciu plazmy. Do badań zastosowano pomiary kąta zwilżania, spektroskopię fotoelektronów wzbudzonych promieniowaniem rentgenowskim (XPS) oraz mikroskopię sił atomowych (AFM). Stwierdzono wpływ oddziaływania plazmy na skład chemiczny i morfologię powierzchni badanych próbek.

EN

The paper reports a investigation on chemical composition and morphology of parylene C samples modified via plasma treatment. Various analytical methods, such as contact angles measurements, X-ray Photoelectron Spectroscopy (XPS) and atomic force microscope (AFM) were used. A significant effect of plasma treatment on chemical composition and polymer surface morphology was found.

7

Badanie wybranych właściwości cyrkonowych powłok ceramicznych natryskanych na stali zaworowej H10S2M

Napadłek W., Gołda M., Przetakiewicz W.

Krzepnięcie Metali i Stopów

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2000

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R. 2, nr 42

253--264

PL

Praca porusza tematykę adiabatyzacji komory spalania przy zastosowaniu termoizolacyjnych powłok ceramicznych na bazie Zr02+8% Y203 oraz z domieszką 30%Al203/Ti02 87113 naniesionych na denko zaworu wylotowego wykonanego ze stali H10S2M. Badane powłoki zostały wykonane metodą natryskania plazmowego (z zastosowaniem międzywarstwy NiAl 70/30) oraz metodą nanoszenia gazodetonacyjnego. W pracy przedstawione są wyniki badań gęstości i porowatości, przyczepności oraz odporności na szoki termiczne opisywanych powłok.