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Camptothecins affinity to HSA and membranes determined by fluorescence anisotropy measurements

Kruszewski S., Burke T.G.

Optica Applicata

2002

Vol. 32, nr 4

721-730

The application of fluorescence spectroscopy methods in determining the properties of camptothecins – promising anticancer agents – is described in this paper. The fluorescence anisotropy measurements provide useful information about the binding of camptothecins to human serum albumin (HSA) and to cell membranes, which is important for potential clinical applications of these agents, and permits the selection from among many camptothecin analogues those the ones exhibiting desirable biomedical properties.