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1

A validated RP-HPLC method for quantitative determination of related impurities of cholic acid bulk drugs

Sheng Z., Ye R., Ge S., Wang C., Xu X., Zhang G., Luo P.

Acta Chromatographica

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2018

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Vol. 30, no. 2

114--118

EN

An efficient and convenient reversed-phase high-performance liquid chromatography method has been developed and validated for the quantitative determination of cholic acid bulk drugs and their related impurities. Chromatographic separation was performed on a YMC-Pack ODS-AQ column (250 mm × 4.6 mm, S-5 μm, 12 nm), and the mobile phase consisted of acetonitrile, methanol, and diluted formic acid solution (pH 2.5) at a flow rate of 1.0 mL/min. The analytes were monitored using a refractive index detector at 30 °C, and the column temperature was 30 °C. Under the above chromatographic conditions, the method has good specificity and specified impurities can be effectively separated. The proposed method is found to have linearity in the 2.0–80.0 μg/mL concentration range with correlation coefficients of not less than 0.9999. The compounds analyzed in the solutions are stable for at least 7 days, and spike recoveries for all specified impurities range from 91.3% to 109.3% with relative standard deviations (RSDs) not more than 7.3%. The limit of detection and the limit of quantification for the analytes are 0.060 μg/mL and 2.0 μg/mL, respectively. The proposed method can be applied in the quality control assay of cholic acid bulk drugs, with the advantages of simplicity, accuracy, robustness, good selectivity, and high sensitivity.

2

Dry ports-seaports sustainable logistics network optimization: considering the environment constraints and the concession cooperation relationships

Wei H., Sheng Z

Polish Maritime Research

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2017

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S 3

143--151

EN

In China dry ports enter into a rapid development period now, however for many Chinese dry ports, the operation faces difficulties duo to inefficient logistics networks and cooperation relationship between dry ports and seaports. Focusing on the concession cooperation mechanism of seaports and dry ports, and the environmental constraints (carbon emissions and congestion cost), a bi-objective location-allocation MILP model for the sustainable hinterland-dry ports-seaports logistics network optimization is formulated, aiming at the system logistics costs and carbon emissions to be minimized. Moreover, for the cooperation mechanism of seaports to dry ports, a parameter called cooperation cost concession coefficient is proposed for the optimization model, and a new evaluation method based on the ordered weighted averaging (OWA) operator is used to evaluate it. Then a location-allocation decision-making framework for the hinterland-dry port-seaport logistics network is proposed. The innovative aspect of the model is that it can proposes a effective and environment friendly dry ports location strategic and also give insights into the connective cooperation relationships, and cargo flows of the network. A case study involving configuration of dry ports in Henan Province is conducted, and the model is successfully applied.

3

The effect of the interface profile on the residual stresses formed in thermally sprayed NiAl coatings on Al2O3 substrate

Golański D., Chmielewski T., Sheng Z.

Przegląd Spawalnictwa

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2014

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R. 86, nr 8

41--47

EN

The physical preparation of a surface material to be coated by the thermal spray processing plays very important role as it affects the bonding force between the coating and substrate. When the coating material has different thermal and physical properties than the substrate the thermal residual stresses are generated in a two material system which may reach the level that promotes the coating delamination or cracking. Another factor influencing the stress state in sprayed coatings may lay in the interface profile between the coating and substrate. We may try to affect this factor by analyzing the profile and texture of the substrate surface to be coated. This way we may influence the residual stress built in a deposited coatings. The aim of this paper is to model and analyze the effect of the substrate surface profile on the residual stresses generated during cooling of thermally sprayed metallic coatings onto the ceramic substrates. The numerical computer simulation has been performed to calculate and compare the residual stress state developed in thermally sprayed metallic/ceramic system (NiAl/Al2O3). The main factor analyzed was the variation in the shape of the interface profile between the coating and substrate. The obtained results have been discussed.

PL

Przygotowanie fizyczne podłoża materiału do natryskiwania termicznego odgrywa bardzo ważną role ponieważ wpływa na stopień powiązania między utworzoną na podłożu powłoką. Gdy materiał powłokowy ma różne właściwości cieplne i fizyczne w stosunku do podłoża to w takim układzie powstaje określony stan naprężeń własnych termicznych, który w zależności od wielkości i rozkładu może prowadzić do pęknięć w powłoce lub jej delaminacji od podłoża. Istotnym czynnikiem wpływającym na stan naprężeń własnych w natryskanej powłoce może być kształt linii połączenia między powłoką a podłożem. Można mieć na niego wpływ poprzez analizę kształtu czy tekstury podłoża przygotowanego do natrysku. W ten sposób możemy wpływać na stan naprężeń w natryskiwanych powłokach. Celem pracy było zbudowanie modelu obliczeniowego oraz analiza wpływu profilu linii połączenia powłoki z podłożem na rozkład naprężeń własnych termicznych powstających w fazie chłodzenia natryskanej na podłoże powłoki. Przeprowadzono obliczenia numeryczne dla układu powłoki NiAl natryskanej na podłoże ceramiki Al2O3. Głównym analizowanym czynnikiem był charakter profilu granicy połączenia między powłoką a podłożem. Wyniki obliczeń naprężeń własnych dla sześciu różnych profili granicy połączenia poddano analizie porównawczej oraz dyskusji otrzymanych wyników.