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Fabrication of Monophasic Strontium Doped Calcium Silicate Granules With Enhanced Osteogenic Performance In The Reconstruction Of Rabbit Bone Defect

Xu Fei, Ghamor-Amegavi Edem Prince, Chong Yu

Acta of Bioengineering and Biomechanics

2023

Vol. 25, no. 3

Advances in the design and manufacturing of novel synthetic bioactive scaffolds as bone substitute in bone reconstruction are at the forefront of orthopedic study due to their excellent biological performances. However, fabricating bioactive scaffolds with similar osteogenic and mechanical properties of a natural bone still remains a challenge. Our aim was to produce functional bioactive scaffolds with biologically interactive ions, microstructure for cell proliferation and a suitable biodegradation rate in critical-size bone defect.