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Terapeutyczne działanie peptydów stosowanych w preparatach kosmetycznych na starzejącą się skórę

Kukowska M., Dzierzbicka K.

Wiadomości Chemiczne

2010

[Z] 64, 7-8

630-643

Dryness of skin, lack of elasticity, laxity, pigmentation, fine lines and wrinkles are the effects of skin aging [1-11]. Researchers and technologists try to fight with these problems. Researchers are still looking for new biologically active substances, which would improve the appearance of skin and technologists are creating a special composition of skin care products. The following publication is a review of currently used biologically active peptides applied in cosmetic products for skin aging (Tab. 1). There are three main groups of peptides with different mechanism of action: neurotransmitter-affecting peptides, carrier peptides and signal peptides [16]. Neuropeptides are peptides, which mimic the action of botulinum neurotoxin (the structure of active toxin is presented in the Fig. 1). These peptides decrease muscle contraction through interactions at the neuromuscular junction [13, 16, 18]. Carrier peptides take part in delivering a cofactor required for wound healing and enzymatic processes into the dermis [16, 28, 29]. Instead, signal peptides are able to stimulate collagen synthesis and cause growth of human dermal skin fibroblasts [16, 18].

Peptydowe koniugaty antrachinonów i ich aktywność biologiczna

Kukowska M., Dzierzbicka K., Maćkiewicz Z.

Wiadomości Chemiczne

2006

[Z] 60, 7-8

523-545

This article concerns methods of synthesis and biological activity of peptidyl anthraquinones. The group of these components have a big influence on a present medicine. Among components, that were presented in this paper, many number of them show antine-oplastic activity. These peptidyl anthraquinones demonstrate special mechanism of action, stabilizing cleavable complex consisting of topoisomerase, convalently attached to DNA and stop correct replication and transcription. Using of topoisomerases inhibitors in therapy of cancer have promising results. Anthraquinones analogues with peptidyl chain including KCR motif very important in AP-1 protein binding to DNA. This group of compounds can be used as potential transcription factor inhibitors, because they show DNA intercalative binding and recognize specific sequences of DNA binding domains. Synthetic GnRH analogues including rings of anthraquinone present interesting drugs using in reproductive diseases, for instance prostate, ovarian and breast cancer. The mechanism of action of GnRH analogues count on binding to GnRH receptors, which we can find in cells of reproductive organs. MMP-9 activity can be exploited to activate prodrugs and be a target the tumour cells in BM. Cleavage of the prodrugs with MMP-9 resulsts in the liberation of the active form of drug which can be an inhibitor of topoisomerase. Tripeptide derivatives of anthraquinone show the activity as histochemical reagents for detection of TTP I activity. Peptidyl anthraquinones can be also used for protein purification and labeled peptides as biochemical probes for DNA detection.