Wyniki wyszukiwania - BazTech

1

Synteza, metody identyfikacji i wybrane medyczne zastosowania dendrymerów

Polcyn P., Janiszewska J., Lipkowski A., Urbańczyk-Lipkowska Z.

Polimery

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2009

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T. 54, nr 6

407-416

PL

Na podstawie przeglądu literatury przedstawiono aktualny stan wiedzy na temat otrzymywania dendrymerów, metod ich charakteryzowania i perspektyw zastosowania w medycynie tej nowej klasy związków polimerycznych.

EN

The present state of knowledge about the preparation, methods of characterization and the prospect of medical applications of dendrimers - a new class of polymeric compounds - is presented on the basis of literature review.

2

Synthesis of Iminosugars from alfa,beta-Unsaturated Lactones and N-Benzyl Nitrone

Panfil I., Urbańczyk-Lipkowska Z., Chmielewski M.

Polish Journal of Chemistry

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2005

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Vol. 79 / nr 2

239-249

EN

1,3-Dipolar cycloadditions of N-benzyl nitrone 12 to D-glycero _-lactone 13 and to D-threo _-lactone 14 proceed with excellent stereoselectivity to provide only one adduct in each case, 16 and 17, respectively. The same reaction performed with L-erythro _-lactone 15 afforded two stereoisomers 18 and 19 in the ratio ca. 2.5:1. Cycloadducts 16-19 were subsequently subjected to a sequence of reactions involving hydrogenolysis of the N-O bond and intramolecular alkylation of the nitrogen atom by C-4 or C-5 carbon atom of the sugar backbone to afford 1,2-dideoxy iminosugars 25, 31, 38, 44 and 50 with a protected hydroxymethyl group at C-2 carbon atom.

3

Studies on Reactions of 3-Benzoyl-4-hydroxypyrido[3,2-e)-1,2-thiazines with Primary Amines and N-Methylhydrazine

Malinka W., Karczmarczyk Z., Kaczmarz M., Świątek P., Urbańczyk-Lipkowska Z.

Polish Journal of Chemistry

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2004

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Vol. 78 / nr 6

815-829

EN

Reaction of the appropriate 3-benzoyl-4-hydroxypyrido[3,2-e]-1,2-thiazine-1,1-dioxides 2 bearing a methyl or a 3-(4-arylpiperazin-1-yl)propyl group at the nitrogen atom of the thiazine ring with primary amines resulted in enamines of type (E)-3. The related products 8 were obtained by alkylation of 3-phenylpyrazolo[4,3-c]pyrido[3,2-e]-1,2- thiazine-5,5-dioxide 7 with the corresponding 1-aryl-4-(3-chloropropyl)piperazines 9. The structures of the new heterocycles 3 and8, synthesized for pharmaceutical purposes, and of the model compounds 4-6, prepared for comparison of spectral properties, were proven through elemental, IR, 1H NMR and, in some cases (3d, 8a), X-ray data.

4

Organometallic dendrimers - molecular architecture and functions

Urbańczyk-Lipkowska Z., Janiszewska J.

Polimery

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2003

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T. 48, nr 1

54-60

EN

Two main methods of dendrimers synthesis - "divergent" (scheme B) and "convergent" one (scheme C) as well as the methods of their structures evaluations have been presented. Organometallic dendrimers differing in metal location: in the core [formulas (I)-(III)], at the interior [formulas (IV) and (V), Fig.1] and on the surface [formulas (VI)-(VIII)] have been discussed. Such dendrimers can work as the carriers and catalysts of chemical, polymolecular inter-phase processes. Especially they can be used as an excellent model systems simulating the action of catalytic centers of enzymes, based on metals.

PL

Przedstawiono dwie główne metody syntezy dendry-merów - rozbieżną (Schemat B) i zbieżną (Schemat C) - oraz metody oceny ich struktury. Omówiono dendrymery metaloorganiczne różniące się umiejscowieniem metalu: w rdzeniu (core) [wzory (I)-(III)], w obszarze wewnętrznym (interior) [wzory (IV) i (V), rys. 1] oraz na powierzchni (surface) dendry-merów [wzory (VI)-(VIII)]. Dendrymery takie mogą służyć jako nośniki i katalizatory w polimolekularnych międzyfazo-wych procesach chemicznych, fizycznych oraz biologicznych. Można je w szczególności wykorzystywać jako doskonałe układy modelowe symulujące działanie opartych na metalach centrach katalitycznych w enzymach.

5

The Synthesis and Structure of Diaza- ans Tetraazacoronands

Lipkowski P., Urbańczyk-Lipkowska Z., Jurczak J.

Polish Journal of Chemistry

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2002

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Vol. 76 / nr 5

729-736

EN

A general method of the synthesis of simple azacoronands via the amidation reaction is presented. Several examples of the X-ray structure studies of the compounds obtained are given.

6

The Role of Steric Hindrance in Molecular recognition Process of 1,4-Diols Obtained from Tartaric Acid

Szczęsna B., Urbańczyk-Lipkowska Z.

Polish Journal of Chemistry

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2000

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Vol. 74, nr 4

495-501

EN

X-ray structure analysis has been done and compared with already known crystal structure of host compound. The lack of complexing properties of the former could be explained by differences in intermolecular hydrogen bonding pattern, expressed by sterically hindered and strain free hydroxy groups. respective solution and solid state IR spectra show the same effect in both media.