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1 2006

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Adhesion and growth of human osteoblast-like cells on aliphatic polyesters with different chemical composition, surface roughness and modification with hydroxyapatite

Vagaska B., Bacakova L., Pamuła E., Lisa V., Dobrzyński P.

Inżynieria Biomateriałów

2006

R. 9, nr 58-60

4-7

In this study we have investigated the effect of three groups of polymeric foils on the behavior of MG 63 osteoblast-like cells. These included (1) poly(L-lactide) (PLLA) compared with newly synthesized copolymer of L-lactide and trimethylene carbonate (PLTMC 50:50), (2) three samples made of glycolide and epsylon-caprolactone copolymer (PGCap) with different surface roughness and topography, and finally (3) copolymer of glycolide with L-lactide (PGLA) compared with its modification with hyroxyapatite deposits. On the 1st and 4th day of cultivation the cell number on all of the samples was lower than on control polystyrene culture dish. However, on day 8 after seeding, the values on the tested samples caught up with the control polystyrene. In the first group the cell number of PLTMC was higher than on polystyrene or PLLA. In the second group, the number of cells on PGCap samples of the lower surface roughness (RRMS 130 and 180 nm) was significantly higher than that on the control polystyrene, whereas on the PGCap samples with the rounghness in micrometers, it was comparable to the value on the polystyrene. Moreover, the surface roughness influenced the cell adhesion area. The cells on the sample with the highest roughness index were roundly shaped and their adhesion area was significantly lower, because the cells were restricted in their spreading by the surface structure of the material. In the last group, the number of cells on day 8 on the polymer with hydroxyapatite deposits was significantly higher than on standard tissue culture polystyrene dish, as well as on unmodified PGLA foil, which suggested that hydroxyapatite supports cell proliferation.