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1 Journal of Medical Informatics & Technologies

1 2003

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Clinical applications of biomechanical simulation

Kruggel F., Tittgemeyer M., Wollny G.

Journal of Medical Informatics & Technologies

2003

Vol. 6

IP3--11

The planning of therapeutical interventions and the understanding of pathological processes may be improved by providing tools for biomechanical simulation. This article focuses on computational services providing numerical simulations for analysis, prediction and virtual prototyping to the medical sector ("bio-numerics"). Two example problems are discussed: (1) The simulation of distraction osteogenesis using Finite Element Models (FEM): Simulations use highly resolved meshes in order to represent the complex midface structures with sufficient detail. Meshes with 1 mm resolutions typically have 1+ million nodes, so forward models must be computed on high performance computing (HPC) platforms. Pre-operative planning involves "playing" with different what-if scenarios so fast response times are highly desirable in order to provide tools that are accepted in a clinical environment. (2) Intra-operative planning in neurosurgery using inverse biomechanical models: Surgically induced deformations invalidate pre-operatively acquired information about functionally relevant areas. This problem is addressed by non-linear registration of pre-operative functional Magnetic Resonance Imaging (MRI) data to intra-operative MRI data.