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1 2006

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Application of 31P Magnetic Resonance Spectroscopy to Observation of Phospholipid Concentration Changes in Blood Serum, Plasma, Peripheral Blood Mononuclear Cells and Bone Marrow Mononuclear Cells from Patients with Hematological Cancers

Tuz M., Kuliszkiewicz-Janus M., Baczyński S.

Polish Journal of Chemistry

2006

Vol. 80, nr 7

1009-1019

Phospholipids play an important role in biological events of progression of cancer. 31P magnetic resonance spectroscopy (MRS) can be a powerful method for non-invasive investigations aiming at explanation of phospholipid mechanisms in tumor tissues and body fluids. 31PMRS was applied to serum, serum with added sodium salt of cholic acid, and phospholipid extracts from plasma, peripheral blood mononuclear cells (PBMC) and bone marrow mononuclear cells (BMMC) from healthy volunteers and patients with hematological cancers. Concentrations of phospholipids were derived from integral intensities of the 31P signals. Observations indicated that phospholipid concentration changes in sera, plasma, PBMC, and BMMC can discriminate between non-responding and responding patients, as well as healthy volunteers. The aim of this review is to show how our scientific group applies 31P MR spectroscopy to study phospholipid metabolism in blood serum, plasma, peripheral blood mononuclear cells and bone marrow mononuclear cells of patients with hematological cancers.