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1
Content available Relationships between acoustical properties and stiffness of soft tissue phantoms
Gambin B., Kruglenko E., Byra M.
Hydroacoustics
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2016
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Vol. 19
111--120
EN
Polyvinyl-alcohol cryogel is commonly used for soft tissue phantom manufacture. The gel formation from an aqueous solution of polyvinyl-alcohol takes place during the freezing and thawing cycle. The aim of this work was to assess the degree of gel solidification, hence the material stiffness, by means of quantitative ultrasound. We manufactured three phantoms which differed in the number of freezing/thawing cycles. First, tissue phantoms were examined with an elastography technique. Next, we measured the speed of sound and the attenuation coefficient. What is more, the inter structure variations in phantoms were assessed with the Nakagami imaging which quantifies the scattering properties of the backscattered ultrasound echo. Obtained results confirmed the connection between the number of freezing/thawing cycles and the solidification p rocess. We d efined th e bo undary layer as a region which has a different structure than the sample interior. Next, for each phantom this layer was extracted based on a Nakagami parameter map. We calculated that the thickness of the boundary layer was lower in samples which were subjected to a larger number of freezing/thawing cycles.
2
Content available Ultrasonic Measurement of Temperature Rise in Breast Cyst and in Neighbouring Tissues as a Method of Tissue Differentiation
Gambin B., Byra M., Kruglenko E., Doubrovina O., Nowicki A.
Archives of Acoustics
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2016
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Vol. 41, No. 4
791--798
EN
Texture of ultrasound images contain information about the properties of examined tissues. The analysis of statistical properties of backscattered ultrasonic echoes has been recently successfully applied to differentiate healthy breast tissue from the benign and malignant lesions. We propose a novel procedure of tissue characterization based on acquiring backscattered echoes from the heated breast. We have proved that the temperature increase inside the breast modifies the intensity, spectrum of the backscattered signals and the probability density function of envelope samples. We discuss the differences in probability density functions in two types of tissue regions, e.g. cysts and the surrounding glandular tissue regions. Independently, Pennes bioheat equation in heterogeneous breast tissue was used to describe the heating process. We applied the finite element method to solve this equation. Results have been compared with the ultrasonic predictions of the temperature distribution. The results confirm the possibility of distinguishing the differences in thermal and acoustical properties of breast cyst and surrounding glandular tissues.
3
Content available Relationship between thermal and ultrasound fields in breast tissue in vivo
Gambin B., Kruglenko E., Wójcik J.
Hydroacoustics
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2015
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Vol. 18
53--58
EN
The study shows the direct relationship between the temperature field and the parallel changes that are taking place in backscattered ultrasonic signals from the breast tissue in vivo when heated to the temperature of approximately 42 deg. C. The non-uniform temperature field inside the heating tissue was determined by the numerical model using FEM. It is shown that the spatial distribution of intensities of the backscattered signals coincides with the temperature distribution field predicted by the numerical model in some areas. The result indicates the possibility of the indirect measurement of the temperature rise in the breast tissue in vivo by measuring the intensity variations of the ultrasound echo.
4
Content available remote Macroscopic thermal properties of quasi-linear cellular medium on example of the liver tissue
Gambin B., Kruglenko E., Gałka A. A., Wojnar R.
Computer Assisted Methods in Engineering and Science
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2015
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Vol. 22, no. 4
329--346
EN
There are two main topics of this research: (i) one topic considers overall properties of a nonlinear cellular composite, treated as a model of the liver tissue, and (ii) the other topic concerns the propagation of heat in the nonlinear medium described by the homogenised coefficient of thermal conductivity. For (i) we give a method and find the effective thermal conductivity for the model of the liver tissue, and for the point (ii) we present numerical and analytical treatment of the problem, and indicate the principal difference of heat propagation in linear and nonlinear media. In linear media, as it is well known, the range of the heat field is infinite for all times t > 0, and in nonlinear media it is finite. Pennes’ equation, which should characterize the heat propagation in the living tissue, is in general a quasi-nonlinear partial differential equation, and consists of three terms, one of which describes Fourier’s heat diffusion with conductivity being a function of temperature T. This term is just a point of our analysis. We show that a nonlinear character of the medium (heat conductivity dependent on the temperature) changes in qualitative manner the nature of heat transfer. It is proved that for the heat source concentrated initially (t = 0) at the space point, the range of heated region (for t > 0) is finite. The proof is analytical, and illustrated by a numerical experiment.
5
Content available Temperature level and properties of wavelet approximations of backscattered ultrasound
Doubrovina O., Gambin B., Kruglenko E.
Hydroacoustics
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2014
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Vol. 17
37--46
EN
The aim of the paper is to find links between the dynamics of changes of statistical parameters and changes in spectral properties of the signal envelope of backscattered RF signals during the thermal process. We have shown previously that by using wavelet approximations these tendencies are better recognized in the case of the heating of a phantom sample than in the parallel analysis performed for a full signal envelope. Here we are currently expanding this statement to the case of heating a soft tissue sample in vitro. The shape parameter of the K- distributed random variable is considered as a statistical marker of temperature level changes. Additionally, the spectral properties of different levels of wavelet approximations are calculated and their sensitivity to temperature increase and decrease is demonstrated. Both approaches registering changes in temperature, are used in the case of the pork loin tissue sample in vitro, heated by an ultrasound beam with a different power.
6
Content available RF signal amplitude statistics during temperature changes in tissue phantoms
Kruglenko E., Gambin B.
Hydroacoustics
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2014
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Vol. 17
115--122
EN
Two heating protocols for soft tissue phantoms have been performed. An Agar-Gel-Oil (AGO) mixture has been heated locally by applying ultrasonic beams and a Poly Vinyl Alcohol-cryogel (PVA-c) has been heated “globally” by a water bath with a controlled temperature rise. The RF signals were collected during heating by an ultrasound transducer to ensure no interference from waves from the heating transducer. Independently, the thermocouples' measurement has been used to obtain temperature as a function of time in the AGO case. At first, a compensation of attenuation was performed and normalized envelopes of signals were used as data for statistical analysis. It is shown that random the values of the backscattered amplitude are close to Rayleigh and K-distributed random variables for AGO and PVA-c, respectively. Temperature is linked to the scale parameter of Rayleigh distribution for the AGO, and the shape parameter of K-distribution for PVA-c were calculated and discussed in the context of their suitability for the acoustic measurement of temperature.
7
Content available Soft tissue-mimicking materials with various number of scatterers and their acoustical characteristics
Kruglenko E., Gambin B., Cieślik L.
Hydroacoustics
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2013
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Vol. 16
121--128
EN
For the study of the temperature increase in the soft tissues irradiated by a low-power ultrasound [1], soft tissue-mimicking materials can be used. The phantoms have been produced based on an aqueous solution of agar, oil, and glass beads microparticles. The RF signals collected in the experiments enabled evaluation of the acoustic properties of phantoms with different number of strong scatterers (concentration varied from 0 to 30 pcs/mm3). Speed of sound (SOS) determined for the phantoms was similar to the value typical of soft tissue (about 1540 m/s). To determine attenuation coefficient the semi-transmission method has been used. Attenuation coefficient value varied from 0.5 to 1.1 dB/(MHz cm), depending on the number of scatterers. It was shown that the phantoms stored for 6 months preserved their acoustical properties and were usable for further experiments. It was found that within the total attenuation, the part corresponding to scattering can be distinguished.
8
Content available Wpływ zmienności właściwości fizycznych tkanki na rozkład temperatury w tkance przy terapeutycznym oddziaływaniu ultradźwięków
Kruglenko E.
Acta Bio-Optica et Informatica Medica. Inżynieria Biomedyczna
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2012
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Vol. 18, nr 4
250--254
PL
Artykuł dotyczy numerycznego wyznaczania in vivo przestrzennego i czasowego rozkładu temperatury po oddziaływaniu na tkankę zogniskowaną wiązką ultradźwiękową małej mocy. Celem pracy jest analiza wpływu parametrów fizycznych tkanki na rozkład temperatury oraz przedstawienie wyników obliczeń dla modelu wątroby szczura, w którym uwzględniono zależność parametrów fizycznych tkanki od temperatury. Wykazano, że przewidywana temperatura tkanki po 20-minutowym oddziaływaniu w większym stopniu zależy od zmiany przewodnictwa cieplnego tkanki niż od jej ciepła właściwego. Parametry materiałowe wody i tkanki wątroby przyjęto na podstawie danych z literatury. Założono, że geometria modelu numerycznego odpowiada rzeczywistemu położeniu obszaru oddziaływania względem głowicy emitującej zogniskowaną wiązkę ultradźwiękową.
EN
The paper concerns the numerical calculation of the spatiotemporal distribution of the temperature field induced by a low power focused ultrasound beam within tissues in vivo. The aim of the study was to analyze the influence of various tissue parameters on the temperature distribution and to present the results of calculations for the rat liver model, taking into account the dependence of physical parameters on the temperature. It was shown that the predicted tissue temperature after 20 minutes of interaction depends more on the tissue thermal conductivity than its heat capacity. The material parameters of water and liver tissue were taken from the literature, and the geometry of numerical model corresponds to the actual location of the interaction area of the transducer emitting highly focused ultrasound beam.
9
Content available Some aspects of numerical modeling of temperature increase due to ultrasound beam irradiation of rat liver
Kruglenko E., Gambin B.
Hydroacoustics
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2011
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Vol. 14
99-110
EN
Some aspects of FEM modeling of hyperthermia, the procedure of tissue temperature rise above 37 oC inside the living organism, as a treatment modality, are studied. Low intensity focused ultrasound (LIFU) beam has been used as a source of temperature rise in the liver tissue during performed experiments in vitro. The comparison of the FEM model of the corresponding heating process and the experimental results has been presented in [1]. In the paper, the FEM model of heating scheme of the rat liver tissue in vivo irradiated by the same ultrasound transducer is formulated. At first, the existence of blood perfusion is taken into account in the model equation. Secondly, the thermal and acoustical properties, which are the input parameters of the numerical model, are taken from the published data in literature. Here, the size and the intensity of heat sources are modeled in two ways on the basis of acoustic nonlinear equation solutions in 3 layers attenuating medium. We demonstrate how the results of FEM model in the case of in vitro and in vivo heating, depend on the assumed power density of heat sources, as well as on the size of the heated area. The results are compared and discussed. The influence of different models on temperature rise profiles are demonstrated.
10
Content available remote Temperature Fields Induced by Low Power Focused Ultrasound in Soft Tissues During Gene Therapy. Numerical Predictions and Experimental Results
Gambin B., Kujawska T., Kruglenko E., Mizera A., Nowicki A.
Archives of Acoustics
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2009
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Vol. 34, No. 4
445-459
EN
The aim of this work is twofold. Firstly, to verify a theoretical model which is capable of predicting temperature fields appearing in soft tissues during their ultrasound treatment. Secondly, to analyze some aspects of the dynamics of Heat Shock Response induced by the heating process in the context of therapeutic treatment. The theoretical investigations and quantitive analysis of temperature increments at any field point versus time of heating process, depending on the heat source power, spatial distribution and duration as well as on the tissue thermal properties, has been carried out by Finite Element Method (FEM). The validation of the numerical model has been performed by comparison of the calculation results with the experimental data obtained by measuring in vitro of the 3D temperature increments induced in samples of the turkey and veal liver by the circular focused transducer with the diameter of 15 mm, focal length of 25 mm and resonance frequency of 2 MHz. Various ultrasonic regimes were considered. They were controlled by adjusting ultrasound power and exposure time. The heat shock proteins (HSP) and misfolded proteins (MFP) levels during the proposed cyclic sonification are presented.
11
Content available remote Miary Younga i ich zastosowania w mikromechanice i optymalizacji. Część I. Podstawy matematyczne
Bielski W., Kruglenko E., Telega J. J.
Matematyka Stosowana : matematyka dla społeczeństwa
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2003
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Nr 4
90-138
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