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1 Acta Chromatographica

1 2003

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Investigation of nicotine transformation products by densitometric TLC and GC-MS

Tyrpień K., Dobosz C., Chróściewicz A, Ciołecka M., Wielkoszyński T., Janoszka B., Bodzek D.

Acta Chromatographica

2003

No. 13

154-160

Samples of nicotine were exposed to air and UV light and the products formed were separated by TLC on RP-18 with acetonitrile-water, 88:12 (v/v), as mobile phase. GC-MS analysis was also performed to confirm the identities of the nicotine transformation products. Cotinine, reported to be one of the main products resulting from the action of environmental agents on nicotine, was identified, as was nicotyrine. The results obtained were compared with nicotine biotransformation products identified in urine from children and pregnant women. trans-3'-Hydroxy-cotinine was identified in these samples but was absent from the products formed by exposure of nicotine to air.