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1 2012

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Artificial extracellular matrices of collagen fibrils and lactoferrin as coatings to enhance osteoblast behavior

Vandorovcova M., Bacakova L., Dubruel P., Douglas T. E. L.

Engineering of Biomaterials

2012

Vol. 15, no. 116-117 spec. iss.

132--134

Lactoferrin, a glycoprotein found in milk, has stimulated osteoblast proliferation and differentiation, but has remained relatively unexplored as a biomaterial component. In this study, artificial extracellular matrices consisting of fibrils of collagen type I containing lactoferrin were used as coatings for the biocompatible polymer poly(lactic-co-glycolic acid) (PLGA). The numbers of cells, their viability and proliferation rate were evaluated in various time intervals. Additionally, cell initial spreading area on day 1 was measured. The results show that lactoferrin accelerates fibril-logenesis, leads to increased osteoblast cell numbers 1 and 3 days post-seeding, and encourages their proliferation in each of the tested time intervals.