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The novel metal complexes with ketoprofen. thermal and spectroscopy investigations

Gacki M., Kafarska K.

Acta Innovations

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2017

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no. 25

47--56

EN

The novel metal complexes of ketoprofen (Hket)(1) with general formulae Mn(L)4(2), Co(L)4(3), Ni(L)4(4), and Zn(L)4(5) (where L= Hket, ket) were synthesized and characterized by elemental analysis, FTIR- spectroscopy and thermal decomposition techniques. All IR spectra revealed absorption bands related to the asymmetric (νas) and symmetric (νs) vibrations of carboxylate group. The Nakammoto criteria clearly indicate that this group is bonded in a bidentate-chelate mode. The thermal behavior of complexes was studied by TG, DTG methods under dynamic condition in air. Upon heating, all compounds decompose progressively to metal oxides, which are the final products of pyrolysis.

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Novel silver complexes with popular non-steroidal anti-inflammatory drugs

Kafarska K., Wolf W. M.

Acta Innovations

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2016

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no. 21

51--59

EN

Non-steroidal anti-inflammatory drugs (NSAID) are class of drugs with antipyretic, analgesic and anti-inflammatory properties. They have also exhibited anti-tumor activity. Even though the mode of their anti-inflammatory activity action is well understood, they exhibit significant adverse effects. Metal complexesation with NSAID may be a promising option for side effects reduction. The novel silver complexes with commonly used non-steroidal anti-inflammatory drugs: ibuprofen, naproxen, mefenamic acid and ketoprofen, were synthesized and characterized by elemental analysis, IR- spectroscopy and thermal decomposition techniques. Coordination of ligands to the silver ions was confirmed by IR spectroscopy. IR data clearly indicate that NSAID anions are bonded in a monodentate mode. The thermal behavior of complexes was studied by TG, DTG and DTA methods in air. Upon heating all compounds decomposed progressively to silver oxide, which was the final product of pyrolysis.

3

Complexes of Mn(II), Cu(II) and Cd(II) with Bipyridine Isomers and Lactates

Czakis-Sulikowska D., Malinowska A., Kafarska K.

Polish Journal of Chemistry

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2006

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Vol. 80, nr 12

1945-1958

EN

The new mixed-ligand complexes containing bipyridine isomers and lactates with formulae Mn(2,4'-bpy)2(lact)2'2H2O, Cu(2,4'-bpy) 2(lact)2, Cd(2,4'-bpy)2(lact)2 . 2H2O, Cd(4-bpy)(lact)2 . 2H2O (where: 2,4_-bpy = 2,4'-bipyridine, 4-bpy = 4,4 '-bipyridine, lact = CH3 CH(OH)COO-) were obtained. These complexes and metal lactates Mn(lact)2 . 2H2O, Cu(lact)2 . 2H2O and Cd(lact)2źH2O were characterized by elemental analysis, IR, conductivity and magnetic measurements. The thermal behaviour of all compounds was studied by thermal analysis (TG, DTG, DTA) in air. A coupled TG/MS system was used to analyse the principal volatile products of thermolysis and fragmentation processes of Cu(II) compounds in air and argon.