Wyniki wyszukiwania - BazTech

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Białka błony zewnętrznej fusobacterium nucleatum jako potencjalny czynnik promocji nowotworu jelita grubego

Lesiów M. K., Krupa K., Komarnicka U. K., Walencik P. K.

Wiadomości Chemiczne

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2018

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[Z] 72, 7-8

585--596

EN

Fusobacterium nucleatum is a Gram-negative, anaerobic bacterium located in an oral cavity. This bacterium can migrate with blood to the different part of the human body e.g colon. The studies suggest participation of Fn in a colorectal cancer promotion, but a particular mechanism of this disease is still unclear. Colorectal cancer leads to million of new death cases each year. It is third in the worldwide in terms of mortality. The predictions for the coming years are not optimistic. The statistics encourage researchers to know the details of the mechanism of colorectal cancer. It is suggest, that outer membrane proteins of Fn are responsible for development of this disease. Transition metal ions such as Cu(I), Cu(II), Fe(II) can coordinate to proteins and generate free radicals by Fenton reaction. Reactive oxygen species (ROS) destroy important biological macromolecules such as DNA, proteins or lipids and cause different diseases. The paper presents characteristics of Fn and its outer membrane proteins, description of copper(II) complexes and their ability to ROS generation.

2

Antybiotyki fluorochinolonowe i ich modyfikacje strukturalne

Komarnicka U. K., Walencik P. K., Lesiów M. K., Krupa K.

Wiadomości Chemiczne

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2018

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[Z] 72, 7-8

543--561

EN

The quinolones are synthetic antibiotics derived from nalidixic acid. Chemical modification of basic structure (nalidixic acid) has led to the development of a group of various compounds currently used in medicine. This article discusses the generation of quinolones, mode of their action, and relationship between activity and structure of these antibiotics. The most common quinolones, lomefloxacin and sparfloxacin were discussed in details, also the therapeutic potential of newer agents was reviewed. Recently, understanding of how molecular modifications among quinolone core structure can affect antimicrobial and anticancer activities has progressed rapidly. In this paper we discussed few examples of fluoroquinolone structural modifications. It was proved that many organic and inorganic compounds derived from fluoroquinolones overcame bacterial drug-resistance. Furthermore, chemical modification improved fluoroquinolone’s anticancer activities.

3

Modyfikacje strukturalne leków - nadzieja w walce z mikroorganizmami i nowotworami

Guz-Regner K., Komarnicka U. K.

Laboratorium - Przegląd Ogólnopolski

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2014

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nr 7-8

28--31

PL

W dobie antybiotykoterapii i chemioterapii komórki nowotworowe, bakteryjne oraz grzybicze stają się oporne na działanie medykamentów. Zsyntezowanie leków, które omijają mechanizmy oporności, nie zawsze prowadzi do pełnego sukcesu. Lekoterapia często wiąże się z niepożądaną reakcją polekową, powodującą różnorodne skutki uboczne. Wszystko to sprawia, że tak istotne staje się opracowanie systemu, który pozwoli wybiórczo niszczyć wyłącznie komórki nowotworowe, bakteryjne lub grzybicze.

EN

In the era of antibiotic therapy and chemotherapy: cancer, bacterial and fungal cells are becoming resistant to medications. Syntheses of drugs which circumvent resistance mechanisms are not always successful. Pharmacotherapy often associates with adverse drug reactions, as well as variety of side effects. This makes it important to develop a system that will selectively destroy cancer, bacterial or fungal cells.