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Characterization of biomaterials with reference to biocompatibility dedicated for patient-specific finger implants

Byrski Adam, Kopernik Magdalena, Major Lukasz, Kasperkiewicz Katarzyna, Dyner Marcin, Lackner Juergen M., Lumenta David B., Major Roman

Acta of Bioengineering and Biomechanics

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2023

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Vol. 25, no. 1

3--17

EN

The research was focused on determining basic mechanical properties, surface, and phase structure taking into consideration basic cytotoxicity analysis towards human cells. Methods: Biological tests were performed on human C-12302 fibroblasts cells using 3D-printed Ti6Al4V alloy (Ti64), produced by laser-based powder bed fusion (LB-PBF) and Alumina Toughened Zirconia 20 (ATZ20), produced by lithography-based ceramic manufacturing (LCM). Surface modifications included electropolishing and hydroxyapatite or hydroxyapatite/zinc coating. Structure analysis was carried out using a variety of techniques such as X-Ray diffraction, scanning electron microscopy (SEM), transmission electron microscopy (TEM) and confocal laser scanning microscopy (CLSM), followed by mechanical properties evaluation using nanoindentation testing. Results: Samples subjected to surface modifications showed diversity among surface and phase structure and mechanical properties. However, the cytotoxicity towards tested cells was not significantly higher than the control. Though, a trend was noted among the materials analysed, indicating that HAp/Zn coating on Ti64 and ATZ20 resulted in the best biological performance increasing cell survivability by more than 10%. Conclusions: Hydroxyapatite coating on Ti64 and ATZ20 resulted in the best biological properties. Tested materials are suitable for in vivo toxicity testing.

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Photosensitive polymeric materials dedicated to lightweight heart pump rotor design

Major Roman, Gawlikowski Maciej, Kurtyka Przemysław, Kustosz Roman, Lackner Juergen M.

Engineering of Biomaterials

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2021

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Vol. 24, no. 163

28

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New design of patient-specific, antimicrobial bioactive finger implants for durable functional reconstruction after amputation

Dyner Marcin, Byrski Adam, Major Roman, Gawlikowski Maciej, Kasperkiewicz Katarzyna, Lackner Juergen M., Dyner Aneta, Major Bogusław

Engineering of Biomaterials

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2021

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Vol. 24, no. 161

8--14

EN

The absence of even a single finger results in a major impairment in the hand function (precise grasping, grip power), therefore significantly affecting the social and professional life of victims who are frequently young people. Finger amputation is a surgical treatment for ~69.000 patients in the EU after traumatic injury, in which replantation microsurgery fails due to the severity of tissue damage. The surgical reconstruction is currently possible only via autograft transplantation, e.g. a toe-to-hand transfer, thus leading to foot impairment. Some motion functional restoration is also possible using a bone-anchored silicone prosthesis but without the sense revalidation. Our current research focuses on alternatives for surgical reconstruction by means of novel patient- -specific, durable, biomimetic, bioactive and antibacterial implants for reconstructing lost bone and joints. The implant design – and the improved micro(neuro) surgery (beyond the project) – will consist in the fast successful rehabilitation, including the soft-tissue related mobility, the implantation of state-of-the-art nerve conduits as well as the aesthetic appearance. Key issues for the long-term functionality of the biomaterial-based reconstruction of hard tissue are based on surgical demands, such as: (1) perfect integration of a bone-substituting metal with the surrounding bone tissue (a) with no signs of loosening due to stress shielding at the interface and (b) enhanced with protective activity against bacterial inflammation (antimicrobial properties and formation of vascularized bone tissue (ossification)) even months to years after the injury; (2) biomimetic finger joints based on non-wearing materials without ossification meant to prevent the loss of the motion function.

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Development of a 3D-printed PCL-TiAlNb material composite with anti-microbial ZnO coating for next-generation maxillofacial implants

Lackner Juergen M., Major Roman, Clement Gullaume, Jabłoński Robert, Kaindl Reinhard, Russmueller Guenter

Engineering of Biomaterials

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2021

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Vol. 24, no. 163

15