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Structural and Spectroscopic Study of trans-Bis(1,3,5-trimethylpyrazole)-bis(O,O'-nitrate) Copper(II) Complex

Wiśniewski Z., Wojciechowska A., Kochel A., Wysokiński R.

Polish Journal of Chemistry

2007

Vol. 81, nr 7

1277-1288

Cu II complex with 1,3,5-trimethylpyrazole (1,3,5-TMePz) trans-[Cu(1,3,5-TMePz)2(NO3)2] has been prepared and studied by X-ray diffraction, vibrational and electronic spectroscopy. The complex crystallizes in the orthorhombic crystal system, P212121 space group with lattice parameters:a = 7.6784(8),b = 13.5856(11), c = 16.3372(13) capital A ring, V = 1704.2(3)capital A ring 3 and Z = 4. The hydrogen bond system stabilizes the crystal structure. Two nitrogen atoms of 1,3,5-TMePz and four oxygen atoms of chelating NO-3 groups form a trans-CuIIN2O2O2 ' chromophore.

Poszukiwanie nowych leków na bazie cisplatyny

Wysokiński R.

Wiadomości Chemiczne

1998

[Z] 52, 7-8

531-544

Cancer therapy is one most the challenging tasks for medicine at the end of this century. The subject of discussion in this paper is cisplatin which about thirty years ago has awaked a hope for an effective treatment of cancer. The following problems have been reviewed : the effect of various substituents on the biological activity of the compounds : cis-PtAm2X2 (where Am is ammine or amine and X is an anionic group), the mechanism of action of cisplatin and the structures of its coordination compounds with DNA. The side effects of cisplatin therapy, in particular its nefrotoxicity and the attempts to establish the structure-activity relationship have been discussed. The second and third generation of platinum-based drugs are presented, including the cisplatin drugs which are joint with some biologically active compounds. They act as the vectors delivering the drug directly to the cancerous cells, hereby decreasing toxicity of these drugs.