Globalization is erasing geographical boundaries, leads to the changes in the economic and political interactions. These new opportunities could be used to develop inter-regional and cross-border relations in various spheres of cooperation between countries. The article deals with issues of formation the Polish-Ukrainian inter-regional and cross-border spaces in the scientific-educational and innovative spheres in the context of smart specialization. The links between smart specializations of Polish and Ukrainian regions could be seen as an important element of joint planning and the coordination of measures support for science, education, and innovations at the inter-State level.
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