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Tubing decontamination during the leak test of iodine-125 seeds

Moura J. A., Moura E. S., Sprenger F. E., Nagatomi H. R., Zeituni C. A., Feher A., Manzoli J. E., Souza C. D., Rostelato M. E.

Nukleonika

2010

Vol. 55, No. 3

409-413

Leak tests were made to detect any leakage of radioactive material from inside the iodine-125 seeds applied in brachytherapy. These seeds are used in prostate cancer treatment. In the quality control routine, during seed production, leak tests are performed according to the International Standard Organization – radiation protection – sealed radioactive sources – ISO-9978 standard, and require liquid transfer between recipients. Any leakage causes contamination of the liquid and tubes. The aim of this study is the establishment of decontamination routines for tubes, allowing their repeated use, in the automated assay process.

Development and production of radioactive sources used for cancer treatment in Brazil

Rostelato M. E. C. M., Rela P. R., Zeituni C. A., Feher A., Manzoli J. E., Moura J. A., Moura E. S., Silva C. P. G.

Nukleonika

2008

Vol. 53, suppl. 2

99--103

The number of cancer patients in Brazil is increasing and part of the patients are submitted to brachytherapy treatment using iridium-192 wire and iodine-125 radioactive seeds. The Nuclear Energy Research Institute established a programme to produce iridium-192 wire and iodine-125 radioactive seeds. With the purpose of settling a laboratory for iridium-192 sources production, a wire activation method was developed and a hot cell for the wire manipulation, quality assurance and packaging was built. The iodine-125 seeds consist of a welded titanium capsule containing iodine-125 adsorbed onto a silver rod. Concerning the setup of the local production, the following activities were carried out: superficial treatment of the silver rod, development of a process to absorb the iodine in the silver rod, welding methodology to seal the seeds, leakage and contamination test and source activity measurement.

Migration measurements from plastic packaging: a simulation study on influence of initial concentration profile

Manzoli J. E., Rosa F. M. L., Silva Felix J., Monteiro M.

Metrology and Measurement Systems

2007

Vol. 14, nr 1

117-124

Migration of components from plastic packaging into foodstuffs or into medicines is a very important issue, concerning public health. Using experimental techniques, like gas chromatography-mass spectrometry, these essays measure total migration and specific migration of components from plastic packaging. This work presents an explanation and applications of a numerical technique tool for this measurement, allowing the comprehension of the diffusion process and the estimate of component migration in difficult or impractical measurements. As an application example, the non-uniform influence of initial concentration profile on the migration is presented, demonstrating the necessity of this profile determination for high quality considerations on involved metrology.