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1 Acta of Bioengineering and Biomechanics

1 2020

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A two-stage model of an arteriovenous fistula maturation process

Jodko Daniel M., Obidowski Damian S., Reorowicz Piotr, Jóźwik Krzysztof

Acta of Bioengineering and Biomechanics

2020

Vol. 22, no. 2

139--153

Purpose: An arteriovenous fistula has been a widely accepted vascular access for hemodialysis, however, a fistula maturation process is still not fully understood. In the short period of time, right after vein and artery shunting, the physical and biological changes take place mainly in the venous wall. A two-stage modeling method of arteriovenous fistula maturation process was proposed and presented. Methods: The first stage of the maturation was modeled with two-way coupled fluid structure interaction computer simulations. Whereas for the second, biological stage, a model was based on the change in the elasticity of the venous wall due to wall shear stress (WSS) modifications. Results: The relation between stress and radial and circumferential strain, based on Lame’s theory, makes possible to introduce a mathematical model defining modulus of elasticity, averaged WSS, and venous diameter as time functions. The presented model enables one to predict changes in the monitored parameters in the arteriovenous fistula taking place in the time longer than 90 days. Conclusions: We found that probably the majority of fistulas can be assessed to be mature too early, when the adequate blood flow rate is achieved but mean WSS still remains at the non-physiological level (>10 Pa).