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2 Inżynieria Biomateriałów

2 2004

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Vascular endothelial cells in cultures on metal/C:H composite films

Bacakova L., Noskova L., Koshelyev H., Biederman H.

Inżynieria Biomateriałów

2004

R. 7, nr 37

18-20

Adhesion, proliferation and maturation of vascular endothelial cells in cultures derived from the bovine pulmonary artery (line CPAE) were studied on Ti/C:H or Ag/C:H films prepared on glass using dc magnetron plasma deposition. The concentration of Ti or AG in the films ranged from 0% to 20%. On Ag/C:H layers, increasing concentration of silver markedly decreased cell viability. Only samples with very low silver content allowed cell spreading and formation of continuous endothelial layer. Although long-term presence of this material in patient's organism would not be advantageous, antimicrobial effect of silver may be favorable for short term applications, e.g. coating of catheters. On Ti/C:H layers, the cells were similarly or more active in adhesion, proliferation and maturation than those on glass or pure amorphous carbon, respectively. This material could be suitable for long-term use in both soft and hard tissue surgery, e.g. for inner coating of vascular prostheses or surface modification of artificial bone implants.

The influence of chemical structure of aliphatic polyesters on adhesion and growth of osteoblast-like MG63 cells

Pamuła E., Bacakova L., Buczyńska J., Filova E., Noskova L., Dobrzyński P., Bero M.

Inżynieria Biomateriałów

2004

R. 7, nr 37

14-17

Degradable copolymers of glycolide and L-lactide (PGLA), glycolide and epsylon-caprolactone (PGCap) and terpolymer of glycolide, L-lactide and epyslon-caprolactone (PGLCap) were synthesized by ring opening polymerization using zirconium acetylacetonate (Zr(acac)4) as a biocompatible initiator. The structure and physicochemical surface properties of the materials were studied by NMR spectroscopy, gel permeation chromatography, X-ray photoelectron spectroscopy and senssile drop. The interaction of polymeric films produced by slip-casting with osteoblast-like MG63 cells were tested in vitro. The number of adhering cells, their shape and the size of cell-material contact area were evaluated from day 1 to 7 after seeding. It was found that the cell behaviour on PGLA and PGLCap was very similar as on control tissue culture polystyrene (TCPS). On PGCap, however, the number of initially adhering cells was significantly lower (by 84% than on TCPS) and cell spreading area smaller (by 50% than on TCPS). On day 7 after seeding, these cells reached the lowest population density (by 30% smaller than TCPS). We hypothesize that the lower cell adhesion and growth of MG63 cells on PGCap was caused by the highest hydrophobicity of this material among all studies samples.