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The Synthesis and Spectroscopic Study of Novel Binuclear Chromium(III) Complex with Pipemidic Acid

Skrzypek D., Kovala-Demertzi D., Szymanska-Niewiadomska B., Kourkoumelis N., Staninska M.

Polish Journal of Chemistry

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2009

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Vol. 83, nr 3

363-371

EN

The interaction of Cr(III) with pipemidic acid, Hpipem, afforded the complex [Cr(pipem)(HO)2(H2O)]2 Cr2O3. The new complex has been characterized by elemental analysis, infrared, XRD and EPR spectroscopy. The EPR spectra of the complex have been recorded down to T = 3 K. The temperature dependence of EPR spectrum demonstrates that spectrum originates from septet transitions at a room temperature and from quintet state for lower temperatures for exchange coupled chromium pairs. The dimer characterizes antiferromagnetic interaction with J = -32 cm-1. The monoanion, pipem, exhibits obligation through the carbonyl and carboxylatooxygen atoms. Six-coordinate dimer distorted octahedral configuration has been proposed for [Cr(pipem)(HO)2(H2O)]2.

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Synthesis and structure of Two thiocarboxypyrazolic Acid Derivatives

Główka M., Błaszczyk M., Prentjas Ch., Kovala-Demertzi D.

Polish Journal of Chemistry

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2004

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Vol.78 /nr 11-12

2013-2022

EN

Two thiocarboxypyrazolic acid amide derivatives were obtained unintentionally in a reaction of thiosemicarbazone with 2-acetylbutyrolactone, and structures of the final products have been determined by X-ray diffraction. Due to conjugation of the thioamide group with the planar pyrazolic ring, the molecule is flat, except 2-hydroxylethyl chain, accidentally adopting similar conformation in the two studied molecules. Also similar is the packing, despite different hydrogen bonding schemes, resulting from the different number of donoric H atoms and the presence of an additional water molecule in the second compound. The mechanism of the reaction is suggested.

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Thin-layer chromatographic estimation of the lipophilicity of some metallic complexes of diclofenac with potential anti-inflammatory activity

Sârbu C., Demertzis M. A., Kovala-Demertzi D.

Acta Chromatographica

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2000

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No. 10

222-230

EN

The relative lipophilicity of seven complexes of diclofenac sodium {[2-[(2,6-dichlorophenyl)amino]phenyl]acetate}, NaL, with Cu2+, Co2+, Ni2+, Mn2+, Fe3+, Fe2+ and Pd2+, with potential anti-inflammatory properties, have been determined by reversed-phase thin-layer chromatography on C18 and CN plates with water–methanol mixtures as mobile phases. The RF values of the compounds increased linearly with increasing concentra-tion of methanol in the mobile phase. Generally, the presence of a cation increases the lipophilicity, expressed as the intercept (RM0), in the same manner. This means that the lipophilic behavior of metallic complexes depends primarily on the structure of ligand, although a more lipophilic effect was observed for Fe2+, Ni2+ and Fe3+ on C18 plates and for Cu2+ and, again, Fe2+ and Pd2+ on CN plates.