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1 Hydraulika i Pneumatyka
1 Polish Journal of Chemistry

2 Will D.
1 Auberval M.
1 Baran R.
1 Breipohl G.
1 Doucet B.
1 Gadek T.
1 Gaillard M.
1 Gourvest J.
1 Knolle J.
1 Peyman A.
1 Ruxer J.
1 Stilz H. U.

1 2005
1 2003

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AlfaVbeta3 Antagonists Based on a Central Benzoic Acid Scaffold

Will D., Breipohl G., Gourvest J., Ruxer J., Doucet B., Auberval M., Baran R., Gaillard M., Gadek T., Knolle J., Stilz H. U., Peyman A.

Polish Journal of Chemistry

2005

Vol. 79 / nr 3

567-572

A series of novel, highly potent _v_3 antagonists based on a benzoic acid scaffold and containing an acylguanidine as an Arg-mimetic and sulfonamide side chains is described. The compounds are selective against the fibrinogen receptor _IIb_3 and they are capable of inhibiting bone resorption in vivo in a TPTX model of osteoporosis. Therefore the compounds are promising drug substances for the treatment of osteoporosis.

Grundladen zur rechnerunterstutzten Vorausberechnung von Druckverlusten in Hydraulikanlagen

Will D.

Hydraulika i Pneumatyka

2003

nr 4

42-45