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Wielka moc w małej cząsteczce : właściwości i zastosowania bisfosfonianów

Kozicka Dominika, Socha Karolina, Szarek Jarosław, Kuźnik Anna

Wiadomości Chemiczne

2023

[Z] 77, 1-2

55--73

Bisphosphonates (BPs) are a group of compounds that are extensively studied around the world. Bisphosphonates are organophosphorus compounds characterized by the presence of the P-C-P skeleton. They are synthetic, thermally stable, and hydrolysis-resistant pyrophosphate analogs that occur naturally in living organisms. BPs have the ability to chelate metals such as magnesium and calcium which results in their high affinity to bone tissue. [1] The above factors determine their biological properties and the wide range of related applications. Bisphosphonates have an established position on the pharmaceutical market and have been used in medicine for many years, mainly as anti-resorptive drugs. They are considered the gold standard in the prevention and treatment of many different bone diseases, such as osteoporosis or Paget disease. [1] The therapeutic potential of bisphosphonates, however, is not limited to the treatment of bone diseases, as more and more reports about their other useful biological properties appear in the literature. [2] The usefulness of bisphosphonates in imaging diagnostics and drug delivery systems is also being explored. [3-5] The following article provides a short literature review on BPs, mainly their structure, properties, and mechanism of action, as well as their current and potential applications.