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1

Cancer therapeutics strategy using nano-carrier mediated natural drugs

Shaw S., Singh P., Mishra R., Singh R., Nayak R., Bose S.

Journal of Achievements in Materials and Manufacturing Engineering

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2022

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Vol. 114, nr 1

32--41

EN

Purpose: Nucleolin is a multifactorial protein, having a significant role in chromatin remodelling, mRNA stability, ribosome biogenesis, stemness, angiogenesis, etc., thus, it is potential therapeutic target in cancer. The purpose of this paper is to study porous silicon (pSi) nanocarrier-based natural drug delivery system targeting dysregulated nucleolin expression for cancer therapeutics. Design/methodology/approach: Quercetin was loaded in pre-synthesized and characterized pSi nanoparticles, and release kinetics was studied. The study compared the inhibitory concentration (IC50) of quercetin, synthetic drug doxorubicin, and quercetin-loaded pSi nanoparticles. Further, mRNA expression of a target gene, nucleolin, was tested with a quercetin treated breast cancer cell line (MCF-7). Findings: Quercetin-loaded pSi nanoparticles followed first-order release kinetics. IC50 was determined at concentrations of 312 nM, 160 μM, and 50 μM against doxorubicin, quercetin, and quercetin-loaded pSi nanoparticles, respectively. The results further indicated 16-fold downregulation of nucleolin mRNA expression after 48h of quercetin treatment of exponentially growing MCF-7 cells. Research limitations/implications: Whether pSi nanoparticle loaded quercetin can significantly downregulate nucleolin protein expression and its impact on apoptosis, cell proliferation, and angiogenic pathways need further investigation. Practical implications: The practical application of the proposed nanocarrier-based drug delivery system potentially lays out a path for developing targeted therapy against nucleolin-dysregulated cancer using natural products to minimize the side effects of conventional chemotherapeutic drugs. Originality/value: Inhibition of nucleolin and nucleolin regulated pathways using natural compounds and its targeted delivery with nanocarrier is not yet done.

2

Dose assessment from the exposure to attached and unattached progeny of radon and thoron in indoor environment

Prasad M., Bossew P., Kumar G. A., Mishra R., Ramola R. C.

Acta Geophysica

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2018

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Vol. 66, no. 5

1187--1194

EN

The radiation dose from the exposure to radon (222Rn) and thoron (220Rn) is mainly contributed by their progeny, not by the gases themselves. This study aims to investigate the health risk associated with the internal exposure to attached and unattached progeny of 222Rn and220Rn in the indoor environment of Garhwal Himalaya, India. For this purpose, the passive measurements of attached and unattached progeny levels of 222Rn and 220Rn were performed in Garhwal Himalaya, India using nuclear track detector based recently developed progeny sensors. The measured values of unattached and total progeny concentrations were used to estimate the unattached fractions and annual effective doses. The annual mean unattached fractions of 222Rn and 220Rn progeny were found to be 0.15 ± 0.04 and 0.17 ± 0.05, respectively. The estimated values of the annual effective doses were found to be 3.4 ± 1.9 mSv/y and 0.7 ± 0.4 mSv/y due to the progeny of 222Rn and 220Rn, respectively. The methodology and results obtained are discussed in details.

3

Ozone Effect On the Properties of Aramid Fabric

Wang Y., Wiener J., Militky J., Mishra R., Zhu G.

Autex Research Journal

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2017

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Vol. 17, no. 2

164--169

EN

The limitation of aramid fiber is its surface property, which results in its very poor interfacial adhesion to most of commercial resins. In order to improve the surface property of the aramid fiber, ozone treatment was carried out in this work. The aramid fabrics were evaluated in terms of surface morphology, wicking effect, tensile property, and ball bursting test. The results showed that the surface morphology of aramid fabrics did not undergo an obvious change; the wicking effect increased slightly with an increase in ozone treatment time; the tenacity and elongation of aramid fibers and fabrics did not significant change after ozone treatment, but the tenacity and elongation of aramid yarns showed significant improvement after ozone treatment, and increased with the increase of ozone treatment time; the ball bursting load and penetration displacement had a slight increase as well after ozone treatment. Therefore, ozone treatment could be one method to improve the surface property of the aramid fiber.

4

3D Numerical Simulation of Laminar Flow and Conjugate Heat Transfer through Fabric

Zhu G., Kremenakova D., Wang Y., Militky J., Mishra R., Wiener J.

Autex Research Journal

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2017

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Vol. 17, no. 1

53--60

EN

The air flow and conjugate heat transfer through the fabric was investigated numerically. The objective of this paper is to study the thermal insulation of fabrics under heat convection or the heat loss of human body under different conditions (fabric structure and contact conditions between the human skin and the fabric). The numerical simulations were performed in laminar flow regime at constant skin temperature (310 K) and constant air flow temperature (273 K) at a speed of 5 m/s. Some important parameters such as heat flux through the fabrics, heat transfer coefficient, and Nusselt number were evaluated. The results showed that the heat loss from human body (the heat transfer coefficient) was smallest or the thermal insulation of fabric was highest when the fabric had no pores and no contact with the human skin, the heat loss from human body (the heat transfer coefficient) was highest when the fabric had pores and the air flow penetrated through the fabric.

5

Structural design engineering of woven fabric by soft computing: part II - non-plain weave

Mishra R., Kremenakova D., Behera B K, Militky J.

Autex Research Journal

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2011

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Vol. 11, no. 2

42--46

EN

The maximum weavability limit is predicted by extending Peirce's geometrical model for non-plain weaves for circular and racetrack cross-sections by soft computing. This information is helpful to weavers in that attempts to weave impossible constructions can be avoided, thus saving time and money. It also helps in anticipating difficulties in weaving and in taking the necessary steps in warp preparation. The relationship between the cover factors in the warp and weft directions is demonstrated for circular and racetrack cross-sections for plain, twill, basket and satin weave. Non-plain weave fabric affords further flexibility for increasing fabric mass and fabric cover. As such, they enlarge the scope of the fabric designer.

6

Structural design engineering of woven fabric by soft computing: part I - plain weave

Mishra R., Kremenakova D., Behera B K, Militky J.

Autex Research Journal

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2011

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Vol. 11, no. 2

37--41

EN

An attempt has been made to optimise the engineering attributes of a plain weave fabric according to certain requirements. A simplified algorithm was used to solve fabric geometrical model equations, and relationships were obtained between useful fabric parameters such as thread spacing and crimp, fabric cover and crimp, warp and weft cover. Such relationships help in guiding the direction for moderating fabric parameters. The full potential of the Peirce fabric geometrical model for plain weave has been exploited by soft computing. The interrelationships between different fabric parameters for jammed structures, non-jammed structures and special cases in which the cross-threads are straight were obtained using a suitable algorithm. It is hoped that the fabric designer will benefit from the flexibility in choosing fabric parameters for achieving any end use with the desired fabric properties.