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2 International Letters of Chemistry, Physics and Astronomy

2 2015

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Synthesis and Antimicrobial Activity of (2-methoxy/2-amino)-6-{4'-[(4'''-chlorophenyl) (phenyl) methyl amino] phenyl}-4-Aryl Nicotinonitrile

Guna J. V., Bhadani V. N., Purohit H. D., Purohit M. D.

International Letters of Chemistry, Physics and Astronomy

2015

Vol. 49

99--103

2- Methoxy – 6 - {4' - [(4'''- Chlorophenyl) (phenyl) methyl amino] phenyl} - 4 - aryl nicotinonitrile (3a-3l) and 2-Amino-6-{4'-[(4'''-Chlorophenyl)(phenyl)methyl amino]phenyl}-4-aryl nicotinonitrile (4a-4l) have been synthesized. The products have been assayed for their antimicrobial activity against Gram +ve, Gram -ve bacteria and fungi. The structure of the products has been elucidated by IR, 1H-NMR, mass spectral data, elemental analysis and thin layer chromatography.

Synthesis and Antimicrobial Activity of 2-{4'-[(4"-aryl)-3"-cyano-2"-methoxy-pyridine-6"-yl]-phenyl amino}-6-[bis(2"'-chloroethyl) amino]-4-Methoxy-1,3,5-Triazine

Kathiriya P. J., Purohit H. D., Purohit M. D.

International Letters of Chemistry, Physics and Astronomy

2015

Vol. 49

143--148

The titled compounds (5a-5k) have been synthesized by the condensation of 2-{4'-[(3"-aryl)-2"-Propene-1"-one]-Phenyl amino}-6-[Bis-2""-chloroethyl) amino]-4-methoxy-1,3,5-triazine with malono nitrile in the presence of sodium methoxide. The biological activities of these compounds have been determined against various Gram +ve, Gram –ve bacteria and fungi. The constitutions of the products are supported by IR, 1 H NMR, Mass spectra and elemental analysis.