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2 International Letters of Chemistry, Physics and Astronomy

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Synthesis and characterization of 1,3,5-trisubstituted pyrazoline derivatives by ultrasonic irradiation method and evaluation of its antibacterial activity

Raguraman A., Santhi N.

International Letters of Chemistry, Physics and Astronomy

2014

Vol. 20, iss. 2

219--233

A series of novel 1,3,5-trisubstituted pyrazoline derivatives (P1-P10) have been synthesized by the reaction of substituted chalcones (C1-C10) with 4-hydroxybenzhydrazide. The starting material, chalcones were prepared by claisen Schmidt condensation of 4-methylacetophenone with substituted aldehydes in the presence of sodium hydroxide in ethanol. 4-hydroxybenzhydrazide was synthesized by condensing methyl 4-hydroxybenzoate with hydrazine hydrate. The cycloaddition of chalcones with 4-hydroxybenzhydrazide gives 1, 3, 5-trisubstituted pyrazoline derivatives. The structures of synthesized derivatives were confirmed by IR, 1HNMR and 13C NMR spectrum. The synthesized compounds were screened for their antibacterial and antifungal activity.

Synthesis, Characterization and Anti-diabetic activity of 1,3,5-triaryl-2-pyrazolines in acetic acid solution under Ultrasound Irradiation

Emayavaramban M., Santhi N., Gopi C., Manivannan C., Raguraman A.

International Letters of Chemistry, Physics and Astronomy

2013

Vol. 9, iss. 2

172-185

A chalcone was prepared by the reaction of 4-methylbenzaldehyde with 4-methylacetophenone in dilute methanolic sodium hydroxide solution under ultrasonic irradiationin the water bath of an ultrasonic cleaner at room temperature. Treatment of this chalcone with thiosemicarbazide / semicarbazide hydrochloride / benzhydrazide / benzenesulphonyl hydrazide / phenylhydrazine hydrochloride afforded the corresponding 2-pyrazoline in good yields. All the new compounds have been characterized by IR, 1H-NMR, 13CNMR spectral data. All the target compounds were evaluated for their in-vivo anti - diabetic activity in rates in comparison with as reference drug.