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1 2015

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Validation of SPME-GC-FID Method for Determination of Fragrance Allergens in Selected Cosmetic Products

Divišová R., Vítová E., Diviš P., Zemanová J., Omelková J.

Acta Chromatographica

2015

Vol. 27, no. 3

509--523

An analytical method for simultaneous determination of 24 legislatively restricted fragrance allergens in various cosmetic products was developed and validated using a combination of solid-phase microextraction and gas chromatography with flame ionization detector. The divinylbenzene-polydimethylsiloxane (DVB-PDMS) fiber was evaluated as the best for extraction of all studied fragrance allergens at 40 °C and 20 min extraction time. All calibration curves showed good linearity in the range of 10-1 to 103 μg Ml-1. Good repeatability and inter-day precision was determined for the proposed method. Detection limits for individual allergens ranged from 0.007 to 2.7 μg Ml-1. The validated method was used to analyze real cosmetic samples. The obtained results indicated that not all of the analyzed cosmetic samples were labeled in accordance with European Cosmetic Directive.