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αBSM failed as a carrier of rhBMP-2 to enhance bone consolidation in a sheep model of distraction osteogenesis

Floerkemeier T., Thorey F., Wellmann M., Hurschler C., Budde S., Windhagen H.

Acta of Bioengineering and Biomechanics

2017

Vol. 19, no. 4

55--62

One of the problems associated with callus distraction is a long time period needed for consolidation of the newly formed bone. The goal of this study was to determine whether percutaneous injections of rhBMP 2 in BSM would enhance bone consolidation. Methods: A unilateral tibial osteotomy combined with external stabilization was performed in 20 adult sheep. After a latency of four days, distraction was conducted for 20 days. Sheep were divided into three groups: group 1 received rhBMP-2/αBSM injections at day 23 and 30, group 2 buffer/BSM injections at day 23 and 30 and group 3 did not receive any injection. The radiographs and in-vivo torsional stiffness measurements were obtained weekly during the following 50 days. Post-mortem bone densitometry (DXA) and mechanical testing were performed. Results: In-vivo stiffness assessments, DXA values and the maximum torsional moment of the sheep tibia treated with two rhBMP-2 injections were not significantly greater than those of both control groups. Conclusions: Presented application of rhBMP-2 in BSM failed to enhance bone consolidation in distraction osteogenesis.

Projektowanie własności resorbowalnych, metalicznych implantów kostnych - zastosowanie w warunkach in vivo

Bach F. W., Kucharski R., Bormann D., Besdo D., Besdo S., Hackenbroich C., Thorey F., Meyer-Lindenberg A.

Inżynieria Biomateriałów

2006

R. 9, nr 56-57

54-58

Celem pracy było określenie stopnia zrostu zwierzęcej kości udowej w warunkach in vivo. Badania przeprowadzono poprzez wykorzystanie metody badania stopnia sztywności w warunkach wzrostu wartości siły w czteropunktowym ugięciu. Do badania zakwalifikowane grupę zwierząt doświadczalnych rasy królik nowozelandzki (New Zealand Rabbit). W pierwszej fazie badań jako wszczepy zastosowano materiały kontrolne z PLA. Wyniki badań określają zarys możliwości zastosowania w chirurgii kostnej materiałów na ubytki kostne wykonanych z resorbowalnych struktur na bazie stopów magnezu. W pracy przedstawiono ponadto metodykę wytwarzania oraz kontrole jakości procesu wytwarzania struktur magnezowych z porami otwartymi z zastosowaniem na implanty w chirurgii kostnej. Tak określone materiały implantacyjne zostaną przebadane w drugiej fazie badań w warunkach in vivo metodą określania stanu sztywności w czteropunktowym ugięciu. Badania umożliwią pełne określenie wpływu implantów na czas i warunki osteosyntezy.

The purpose of the dissertation was to optimize the casting method of producing the magnesium alloy implants for the purpose of filling bone defects. Characteristics of the resulting material structure were tested using computer micro-tomography. Also the mechanical properties were tested. The results obtained had a direct impact on the design of the size of pores and thickness of internal walls of the spongy metallic materials. The dissertation also presents the methodology and results of the testing adhesion of the animal femoral bone in vivo. The evaluation of the bone reconstruction was performed using the method of four-point bending. The tests were carried out on the New Zealand Rabbit experimental animals. First stage of the tests concerned measuring of the stiffness in vivo, in which the PLA control materials were used. The research results obtained in vivo set out the possibilities of designing resorbing structures with open pores derived on the basis of magnesium alloys for the purpose of the application in the bone surgery as filling materials for bone defects.