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2 Optica Applicata

2 2002

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Quantitative measurements of the fluorescence intensity - new method for a detection of melanoma cells in histopathological preparations

Chwirot B.W., Sypniewska N., Barcikowska E.

Optica Applicata

2002

Vol. 32, nr 4

613-623

Formalin-induced fluorescence (FIF) allows for a detection of human melanoma. Microscopic digital imaging was used to determine quantitatively the FIF intensity. Melanomas were detected with a sensitivity of 82% and a specificity of 66%, i.e., better than reported earlier. Also 70% of melanomas in a vertical and 83% of melanomas in a horizonthal growth phase were classified correctly. Changes in the FIF intensity seem to be correlated with a progress of the disease. Determination of molecules involved in the FIF emission may lead to a discovery of an antigen specific to human melanoma. That might pave a way to elaborating first specific immunohistologic technique for detecting the cells of human melanoma.

Fluorescence detection of human tumours without photosensitisers

Chwirot B.W., Chwirot S.

Optica Applicata

2002

Vol. 32, nr 4

625-639

Autofluorescence detection of human cancer has made rapid progress with several groups reporting very promising data for the detection of premalignant and malignant lesions in several locations. The coming years will most probably see a transfer of the autofluorescence methods to clinical practice, especially if the research and development of new instruments will be supported by fundamental studies on the origin of the autofluorescence. Controlled multicentre trials and outcome analysis studies are still necessary to prove the benefits but the results obtained up to now have been very optimisti.