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Content available remote System-level modeling of a Lab-On-Chip for micropollutants detection
EN
The issue addressed by this paper is system-level modeling of Lab-On-Chip (LOC) level. These microsystems integrate within a single chip many functions from several domains such as electronics, thermic, biochemistry or microfluidics. The modeling of these systems in a single environment and the interface between different domains is very challenging. In this paper, we propose some methods to model the entire system in VHDL-AMS. The models are developed and assembled from elementary building blocks, with a validation through experiments or numerical simulation on a reference tool, toward the complete LOC. For each domain, the modeling methodology is described. The principle is applied to a specific use case: a LOC designed for the detection of micro-pollutants in drinking water. It is based on the ELISA test leading to a pH-shift which is in turn detected by an Ion-Sensitive Field Effect Transistor (ISFET). In the last part of the paper, the first results obtained with the complete zero-order model of the LOC are described. Of course, this model has to be improved in order to be faithful to the actual LOC but it will undoubtedly be a major asset for the optimization and reliability improvement of the LOC.
2
EN
Synthetic biology is an emerging area of biotechnology for which main applications are in the field of Health and Environment However, it suffers from a lack of adapted CAD tools and methodology in order to fulfill efficiently and quickly the needs of these domains. In this paper, the strong relationship between circuits design in microelectronics and synthetic biology is highlighted. Most of synthesized biodevices behavior can be interpreted and modeled by BioLogic gate. As a consequence, bigger biosystems might be designed using methods and tools borrowed from microelectronics. These similarities lead to an efficient methodology, using microelectronics design flow, tools and methods, which should allow a top-down approach in synthetic biosystem design. The methodology is illustrated on the design of a biosystem (a T-flipflop), using top-down approach and HDL modeling languages. The proposed methods and their evolution prospects are discussed at the end of the paper,
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