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Content available remote Membranes affinity of hydroxycamptothecins, anticancer agents, determined by fluorescence spectra analysis
Cyrankiewicz M., Ziomkowska B., Kruszewski S.
Optica Applicata
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2006
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Vol. 36, nr 2-3
209-215
EN
In this paper the method of determination of membranes affinity of hydroxycamptothecins is described. Under physiological conditions hydroxycamptothecins easily hydrolyze and convert into inactive carboxylate form. The process of deactivation is inhibited when the molecules of drug are bound to cell membranes so it is desirable that hydroxycamptothecins molecules bind easily to membranes. A quantitative measure of drugs affinity to membranes is the association constant. To determine this parameter the small unilamellar liposomes are used as model membranes. The affinities of 10-hydroxycamptothecin, SN-38 and DB-67 to membranes are determined. The association constants are calculated on the basis of changes of fluorescence spectra.
2
Content available remote Deactivation rate of camptothecin determined by factor analysis of steady-state fluorescence and absorption spectra
Ziomkowska B., Kruszewski S., Siuda R., Cyrankiewicz M.
Optica Applicata
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2006
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Vol. 36, nr 1
137-146
EN
Camptothecin is a fluorescent compound exhibiting strong anticancer properties. A serious limitation to clinical application of this compound is its hydrolysis, when biologically active lactone form converts into inactive carboxylate. There are some differences in the shapes of both fluorescence and absorption spectra of the lactone and carboxylate forms of camptothecin. Therefore, during hydrolysis resultant fluorescence and absorption spectra evolve. Factor analysis of fluorescence/absorption spectra recorded during the hydrolysis process of camptothecin enables one to determine the temporary concentration of the lactone and carboxylate forms and obtain the deactivation rate of this compound.
3
Content available remote Affinity of new anticancer agent, DB-174, to membranes and HSA determined by fluorescence spectroscopy methods
Kruszewski S., Bom D., Ziomkowska B., Cyrankiewicz M.
Optica Applicata
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2006
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Vol. 36, nr 2-3
199-207
EN
The application of fluorescence spectroscopy methods to determining the properties of camptothecins promising anticancer agents are described in this paper. The fluorescence anisotropy measurements provide useful information about the binding of camptothecin and its analogues to cell membranes and human serum albumin (HSA) that is important for potential clinical applications of these agents, and permits the selection from many camptothecin analogues those ones exhibiting desirable biomedical properties. Binding properties of 7-trimethylsilyl-ethyl-10 hydroxy-camptothecin are the subject of this paper.
4
Content available remote Application of principal component and factor analysis of fluorescence spectra in camptothecin studies
Kruszewski S., Siuda R., Ziomkowska B., Cyrankiewicz M.
Optica Applicata
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2003
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Vol. 33, nr 2-3
369-380
EN
The application of fluorescence spectroscopy methods in investigations of camptothecin (CPT) is presented in this paper. Fluorescence of CPT enables one to follow the process of hydrolysis, i.e., the process of converting the biologically active lactone form into inactive carboxylate. The fluorescence spectra of CPT recorded during the hydrolysis were analysed using principal component analysis (PCA) and factor analysis (FA). The results obtained on the basis of fluorescence spectra analysis are compared with high performance liquid chromatography (HPLC) data.
5
Content available remote Model multilineal pattern formation : a computer experiment
Gadomski A., Cyrankiewicz M.
Computational Methods in Science and Technology
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2001
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Vol. 7, nr 2
75-90
EN
Multilineal pattern formation in the square lattice is studied. It turns out that lognormality both in space (size) and time appears to be a main signature thereof. A diffusive character of the emerging patterns has been emphasized, and some elucidation, supporting an understanding of the model phenomenon in question is provided. Excursions towards dynamics of the multiline as well as a relation to known kinetic or dynamic models have been offered as well.
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