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A pattern recognition approach to Emery-Dreifuss muscular dystrophy (EDMD) study

Sokołowska B., Jóźwik A., Niebroj-Dobosz I. M., Hausmanowa-Petrusewicz I.

Journal of Medical Informatics & Technologies

2014

Vol. 23

165--172

The algorithms of pattern recognition were used for differentiation between two forms of Emery-Dreifuss muscular dystrophy (EDMD), i.e. autosomal-dominant laminopathy (AD-EDMD) and Xlinked emerynopathy (X-EDMD). A set of some matrix metalloproteinases (MMPs) and their tissue inhibitors (TIMPs) in serum of EDMD patients and healthy subjects were treated as features. In concluding MMPs and TIMPs levels are helpful to identifying the EDMD patients and the disease progress.

Assessment of human motoneuron afterhyperpolarization duration in health and disease

Piotrkiewicz M., Kudina L., Jason Chen J. J., Hausmanowa-Petrusewicz I.

Biocybernetics and Biomedical Engineering

2012

Vol. 32, no. 3

43-61

The results of the investigatigation of afterhyperpolarization (AHP) duration in normal aging and selected neuromuscular disorders are presented. This investigation yielded unexpected results: the AHP shortening in myogenic disease (DMD) and no significant difference from control values in neurogenic disease (ALS). However, introduction of age factor revealed novel aspects of the human ALS, which can be interpreted on the basis of the results obtained in a SOD1 mice, thus confirming usefulness of this animal model of ALS. In spastic patients the AHP was prolonged and the difference from the control AHP duration decreased with age and disease duration. Our results suggest that the match between temporal characteristics of the AHP of MN and of the twitch of its muscle unit is preserved during normal aging and in spasticity, but not in the DMD.