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1
Content available remote HPLC analysis and blood-brain penetration of 20-hydroxyecdysone diacetonide
Kalász H., Hunyadi A., Tekes K., Dolesal R., Karvaly G.
Acta Chromatographica
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2017
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Vol. 29, no. 3
375--383
EN
Blood-brain penetration of 20-hydroxyecdysone 2,3;20,22-diacetonide (20DA) has been scouted using chromatographic methods. In vivo experiments were performed by treating male Wistar rats intraperitoneally (i.p.) with a dose of 50 mg kg−1 20DA. Control experiment was done by using 20-hydroxyecdysone (20E). Definite brain penetration of 20DA was found by using high-performance liquid chromatography (HPLC), while 20E does not show this type of distribution.
2
Content available remote HPLC analysis and detection of l-deprenyl
Csomor V., Laufer R., Pöstényi Z., Kalász H., Adeghate E., Nurulain S. M., Tekes K., Adem A.
Acta Chromatographica
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2014
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Vol. 26, no. 4
649--656
EN
l-Deprenyl and its major metabolites were subjected to reversed-phase high-performance liquid chromatography (HPLC). The separation was monitored using both ultraviolet (UV) and electrochemical detectors. Ultraviolet absorbance detected l-deprenyl, l-nordeprenyl, l-methamphetamine, and l-amphetamine. Amperometric detection was specific and sensitive to the parent compound (l-deprenyl, a tertiary amine) only. Peaks of the major L-deprenyl metabolites did not give any comparable signal using amperometric monitoring.
3
Content available remote HPLC analysis in drug level monitoring of K027
Nurulain S. M., Kalász H., Szegi P., Kuca K., Adem A., Hasan M. Y. B., Hashemi F., Tekes K.
Acta Chromatographica
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2013
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Vol. 25, no. 4
703--710
EN
HPLC monitoring of pharmacokinetics was done in two body compartments of rats following intramuscular treatments with three different doses of K027, a bispyridinium mono-aldoxime type of antidotes to organoposphate intoxicated subjects. Reversed-phase HPLC separation with electrochemical detections was done to monitor the onset, the maximum level, and offset in K027 concentration. Serum level of K027 showed a fast onset, independently from the doses of K027. Drug level in brain was showing an essentially delayed kinetics.
4
Content available remote HPLC monitoring of the microsomal stability of rutin and quercetin
Szőke É, Petroianu G., Tekes K., Benkő B, Szegi P., Laufer R., Veress G
Acta Chromatographica
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2009
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Vol. 21, no. 3
399--410
EN
Reversed-phase HPLC has been used to monitor the concentration of the two major Chamomile components rutin and quercetin during rat liver microsomal treatment. The possibility of microsomal oxidative metabolism or stability of these two components was examined using a guard-column without any clean-up. The concentration of quercetin decreased when exposed to rat liver microsomal media whereas the rutin concentration did not change significantly over one hour of treatment.
5
Content available remote HPLC study of the pharmacokinetics of K-203
Kalász H., Laufer R., Szegi P., Kuca K., Musilek K., Tekes K.
Acta Chromatographica
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2008
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Vol. 20, no. 4
575-584
EN
The pharmacokinetics of K-203, a recently synthesized bis-pyridinium aldoxime, have been investigated by reversed-phase HPLC. The K-203 content of serum samples was monitored by HPLC with ultraviolet absorbance detection at 286 nm. The low concentration of K-203 in samples of brain, eyes, and cerebrospinal fluid was also determined by HPLC; quantitative evaluation was possible by use of an amperometric detector.
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