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Iridoid Glucoside and Aryl Ester from Buddleja crispa

Ahmad I., Malik A., Afza N., Fatima I., Tareen R., Nawaz S., Choudhary M.

Polish Journal of Chemistry

2006

Vol. 80, nr 9

1483-1491

Iridoid glucoside (1) and aryl ester (2) have been isolated from Buddleja crispa along with buddlejosides A2 (3) and A5 (4) isolated for the first time from this species. The structures of all of the compounds were determined by spectroscopic techniques and chemical studies. Compound 1 displayed lipoxygenase inhibitory potential with an IC50 value of 52.5 š 0.03 mi M while compound 2 inhibited acetylcholinesterase and butyrylcholinesterase enzymes with IC50 values of 36.5 š 0.03 mi M and 12.5 š 0.02 mi M, respectively.