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Reactor Laboratory for Biomedical Research in National Centre for Nuclear Research in Poland

Michaś Edyta, Dorosz Michał, Wójciuk Karolina, Tymińska Katarzyna, Wiliński Maciej, Maciak Maciej, Domański Szymon, Wojtania Grzegorz, Bartosik Łukasz, Małkiewicz Adam, Lechniak Jan, Gryziński Michał Aleksander

Polish Journal of Medical Physics and Engineering

2021

Vol. 27, Iss. 1

119--122

National Centre for Nuclear Research, NCBJ is one of the biggest research institutes in Poland, in which scientists deal with basic research in the various fields of subatomic physics, development of nuclear technologies and practical applications of nuclear physics methods, including those for nuclear medicine and radiotherapy. NCBJ operates the only Polish nuclear research reactor MARIA, around which a Reactor Laboratory for Biomedical Research, RLBR has been built in the last 4 years. One of the main aims of the RLBR team is to adapt the H2 channel, one of the eight MARIA’s horizontal channels, to a specific irradiation facility delivering a high flux thermal/epithermal neutron beam. The beam derived from the channel will be a tool for biological, physical and material studies for Boron Neutron Capture Therapy, BNCT. While NCBJ is focused on building a neutron research facility, the Polish scientific community expressed its interest in BNCT development and implementation as an alternative therapy for cancer treatment. Through the working group meetings organized in the form of regular scientific workshops since 2015, it led to the establishment of a national scientific consortium dedicated to BNCT. Polish Consortium for Boron Neutron Capture Therapy agreement was initially signed by twelve institutions including scientific institutes, universities and oncological centres in October 2019. National Centre for Nuclear Research was appointed the leader of the consortium. A year later the consortium was enlarged by two more institutions.

Calculated neutron energy dependence of the dose-response of large recombination chamber

Tymińska Katarzyna, Gryziński Michał A., Maciak Maciej

Nukleonika

2019

Vol. 64, No. 4

117--121

A model of REM-2-type chamber was modeled with MCNPX code to study the dose-response to monoenergetic neutrons in wide energy range from thermal to 20 MeV for various compositions of gas in the chamber. The energy dependence of the total dose absorbed in the fi lling gas was compared with the energy dependence of ambient absorbed dose D*(10) and with experimental data. The results of the studies will be useful for designing new, improved generation of recombination chambers.

Badania nad terapią BNCT w Polsce i na świecie

Knake Natalia, Maciak Maciej, Maliszewska-Olejniczak Kamila, Tymińska Katarzyna, Murawski Łukasz, Madejowski Gaweł, Wójciuk Karolina, Michaś Edyta, Wojtania Grzegorz, Kuć Michał, Dróżdż Agnieszka, Gryziński Michał A.

Inżynier i Fizyk Medyczny

2019

Vol. 8, nr 4

289--295

Przy Reaktorze MARIA w Narodowym Centrum Badań Jądrowych (NCBJ) powstaje stanowisko do badań nad terapią borowo-neutronową (BNCT). Terapia polega na napromienianiu nowotworu wiązką neutronów o odpowiednich parametrach po uprzednim podaniu pacjentowi związku boru, który w wyniku określonych mechanizmów gromadzi się głównie w komórkach rakowych. W wyniku reakcji 10B(n,α)7Li emitowane są cząstki jonizujące powodujące zniszczenie tylko tych komórek, w których zgromadzony jest bor [1]. Badania kliniczne prowadzone na świecie potwierdzają skuteczność metody, otwierając nowe perspektywy dla jej zastosowania w terapii konwencjonalnej.

The stand for research on Boron Neutron Capture Therapy (BNCT) at the MARIA Reactor at the National Centre for Nuclear Research is being created. The therapy consists of irradiation of the tumour with a neutron beam with specific parameters after prior administration of the boron compound to the patient, which accumulates mainly in cancer cells as a result of specific mechanisms. As a result of 10B(n,α)7Li reaction, ionising particles are emitted and destroy only those cells, in which boron is accumulated. Clinical trials conducted in the world show relatively high efficiency of BNCT, opening new perspectives for its use in conventional therapy.