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1
Content available Mechanical Properties of Polymer Coatings Containing HAp and Active Substance on a Metal Substrate
Goldsztajn Karolina, Lisoń-Kubica Julia, Jaworska Joanna, Jelonek Katarzyna, Kajzer Wojciech, Szewczenko Janusz
Tribologia
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2023
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nr 2
17--25
EN
Titanium alloys are currently widely used in implantation, especially in orthopaedics. However, undesirable reactions caused by aluminium and vanadium ions released from the surface of the most commonly used alloys, Ti6Al4V and Ti6Al7Nb, result in the need to modify the surface of the material to improve biocompatibility. Among the available modification methods, one can mention the application of biodegradable polymer coatings, which, apart from improving biocompatibility by limiting the penetration of alloying element ions into the tissue environment, can also be a matrix for the release of mineral (HAp) and active substances. The paper attempts to determine the mechanical properties of PLGA polymer coatings containing nanoparticle hydroxyapatite and an active substance (dexamethasone) applied with the ultrasonic spray coating method on a Ti6Al7Nb alloy substrate. The scope of the research included: surface topography testing using an optical profilometer, coating adhesion testing to the substrate using the scratch test method and tribological testing (Pin-On-Disc method).
PL
Stopy tytanu znajdują obecnie szerokie zastosowania implantacyjne, szczególnie w ortopedii. Jednakże niepożądane reakcje wywoływane przez jony glinu i wanadu uwalnianie z powierzchni najczęściej wykorzystywanych w praktyce stopów Ti6Al4V oraz Ti6Al7Nb skutkują koniecznością modyfikacji powierzchni materiału w celu poprawy biokompatybilności. Wśród dostępnych metod modyfikacji wymienić można nakładanie biodegradowalnych powłok polimerowych, które poza poprawą biokompatybilności poprzez ograniczenie przenikania jonów pierwiastków stopowych do środowiska tkankowego stanowić mogą także matrycę dla uwalniania substancji mineralnych (HAp) oraz aktywnych. W pracy podjęto próbę określenia własności mechanicznych powłok polimerowych z PLGA, zawierających nanocząsteczkowy hydroksyapatyt oraz substancję aktywną (deksametazon), nakładanych metodą natryskiwania ultradźwiękowego na podłoże ze stopu Ti6Al7Nb. Zakres przeprowadzonych badań obejmował badania topografii powierzchni z wykorzystaniem profilometru optycznego, badania adhezji powłok do podłoża metodą scratch test oraz badania tribologiczne (metoda Pin-On-Disc).
2
Content available Physical properties of materials used for infusion sets for photosensitive medicines
Szafarczyk Karolina, Szewczenko Janusz, Maciak Erwin, Kałużyński Piotr, Goldsztajn Karolina
Engineering of Biomaterials
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2022
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vol. 25, no. 167
2--9
EN
Continuous infusion, as one of the most effective methods of delivering pharmaceuticals to patients, uses infusion pumps to which a syringe and infusion drains are connected. Photosensitive drugs that require UV-VIS protection are delivered to patients with special infusion sets that reduce harmful radiation. However, these drains have different transparencies, which can affect the success of therapy. This study investigated the optical properties of two types of drains used for infusion therapy of photosensitive drugs. UV-VIS spectroscopy studies were carried out, allowing the determination of the absorbance values and absorption coefficient of the two types of drains. The spectrum of their transmittance was also analyzed. The chemical composition of the samples was tested using FTIR-ATR spectroscopy. Furthermore, the roughness and wettability parameters of the drains were determined, which affect not only the kinematics of drug flow in the drains but also the way in which light is transmitted. The results of the study can be used to propose a solution to eliminate the problem of loss of properties of the photosensitive drug in drains, in contact with light. By selecting the appropriate drain thickness, it is possible to reduce the transmission of radiation in the UV-VIS range through the drain.
3
Content available Modern methods of surface modification for new-generation titanium alloys
Lisoń-Kubica Julia, Taratuta Anna, Goldsztajn Karolina, Antonowicz Magdalena, Walke Witold, Dyner Aneta, Basiaga Marcin
Acta of Bioengineering and Biomechanics
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2022
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Vol. 24, no. 4
147--158
EN
The constantly growing need for the use of implants in osteotomy is mainly due to the aging population and the need for long-term use of this type of biomaterials. Improving implant materials requires the selection of appropriate functional properties. Currently used titanium (Ti) alloys, such as Ti6Al4V and Ti6Al7Nb, are being replaced by materials with better biocompatibility, such as vanadium(V) or niobium (Nb), allowing for creation of the so-called new generation alloys. These new alloys, with the incorporation of zirconium (Zr), iron, and tantalum, possess Young’s modulus close to that of a bone, which further improves the improves the biomaterial’s. biocompatibility. This article describes the atomic layer deposition (ALD) method and its possible applications in the new generation of titanium alloys for biomedical applications. Also, the exemplary results of tin oxide (SnO2) thin coatings deposited by ALD and physical vapor deposition (PVD) methods are presented. This study aimed to evaluate the physicochemical properties of a Ti13Nb13Zr alloy used for elements in the skeletal system. As the temperature and the number of cycles vary, the results demonstrate that the surface area of the samples changes. The uncoated Ti13Nb13Zr alloy exhibits hydrophilic properties. However, all coated specimens improve in this respect and provide improved clinical results. after the applied modification, the samples have a smaller contact angle, but still remain in the range of 0–90°, which makes it possible to conclude that their nature remains hydrophilic. Coating the specimens decreased the mineralization risk of postoperative complications. As a result, the biomaterials demonstrated improved effectiveness, decreased complication indicators, and improved patient well-being.
4
Content available Physical properties of PLGA biodegradable polymer coatings containing hydroxyapatite on Ti6Al7Nb substrate
Goldsztajn Karolina, Szewczenko Janusz, Jaworska Joanna, Jelonek Katarzyna, Basiaga Marcin
Engineering of Biomaterials
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2021
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Vol. 24, no. 163
31
5
Content available Bioresorbable vascular scaffolds - effect of coating parameters on morphology and dose of antirestenotic drug
Jelonek Katarzyna, Jaworska Joanna, Musiał-Kulik Monika, Stojko Mateusz, Sobota Michał, Włodarczyk Jakub, Pastusiak Małgorzata, Szewczenko Janusz, Goldsztajn Karolina, Dobrzyński Piotr, Kasperczyk Janusz
Engineering of Biomaterials
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2021
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Vol. 24, no. 163
81
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