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1 Polish Journal of Chemical Technology

1 2024

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Exosome-hydrogels loaded with metal-organic framework improve skin aging by inhibiting oxidative stress

Li Li-Jie, Han Qing-Ling, Feng Wen-Jie, Wang Zhan-Peng, Li Hong-Hua

Polish Journal of Chemical Technology

2024

Vol. 26, nr 2

42--47

Solvothermal reactions of Ba(NO3)2 with 1,3,5-benzenetricarboxylic acid gave rise to a new coordination polymer of [Ba6(BTC)4(H2O)9]}n (1 H3BTC = benzenetricarboxylic acid). The complex 1 was characterized soundly by Fourier transform infrared (FT-IR) spectroscopy, elemental analysis (EA), single-crystal X-ray diffraction (SCXRD), and thermogravimetric analysis (TGA). The framework of 1 has high thermal stability and shows intense luminescence at room temperature. Hyaluronic acid (HA) and carboxymethyl chitosan (CMCS) have good biocompatibility, based on the chemical synthesis method, the HA/CMCS hydrogel was prepared. With exosomes as drug models, we further synthesized novel exosome-loaded metal gel particles and evaluated their effects on oxidative stress in human dermal fibroblasts.