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A pH-responsive biopolymer-based multiple emulsion prepared in a helicoidal contactor for chemotherapeutics delivery

Dluska Ewa, Markowska-Radomska Agnieszka, Skowronski Patryk

Polimery

2022

Vol. 67, nr 7-8

346--354

Among biopolymers, pH-responsive ones have much potential for drug delivery systems by exploiting the pH gradient between physiological and pathological states. In this paper multiple emulsions with a pH-responsive biopolymer for controlled drug delivery in brain tumor treatment were discussed. The characteristic and rheological properties of multiple emulsions, biopolymer adsorption, zeta potential, and release processes were examined. The results showed higher drug release rates in the acidic tumor microenvironment compared to the simulated conditions of normal cells.

Wśród biopolimerów, te reagujące na pH wykazują duży potencjał w systemach dostarczania leków dzięki wykorzystaniu gradientu pH między stanami fizjologicznymi i patologicznymi. W pracy omówiono emulsje wielokrotne z biopolimerem reagującym na zmiany pH, do kontrolowanego dostarczania leków w terapii guza mózgu. Zbadano charkterystykę i krzywe reologiczne emulsji, adsorpcję polimeru na kroplach, zeta potencjał i proces uwalniania. Wyniki wykazały wyższe szybkości uwalniania leku w kwaśnym mikrośrodowisku guza w porównaniu z symulowanymi warunkami normalnych komórek.

Multiple emulsions for simultaneous active agents delivery in a skin topical application

Markowska-Radomska Agnieszka, Dluska Ewa, Metera Agata, Wojcieszak Maria

Chemical and Process Engineering

2021

Vol. 42, nr 3

263-–273

Most antiseptic agents are intended for use on intact skin, e.g. for hand hygiene or skin preparation before any medical procedure. This paper presents multiple emulsion-based antiseptic agents as formulations for application to body surfaces with modified release rates. Multiple emulsions with a co-encapsulated antiseptic (phenyl salicylate – salol) and an agent preventing microorganism growth (benzoic acid) were formed in a Couette–Taylor flow apparatus. Results confirmed the possibility of the release kinetics modification while two compounds were encapsulated in the internal droplets of emulsions to control the release rates and time of the dose release. The addition of benzoic acid as a second active compound of the encapsulation process in the internal phase of double O1/W/O2 emulsion reduced the time necessary for the total release of salol triggering a two-step release.