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1 International Journal of Microelectronics and Computer Science

1 2014

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System-level modeling of a Lab-On-Chip for micropollutants detection

Guiton S, Rezgui A, Madec M., Lallement C., Rufi F, Haiech J.

International Journal of Microelectronics and Computer Science

2014

Vol. 5, nr 3

116--125

The issue addressed by this paper is system-level modeling of Lab-On-Chip (LOC) level. These microsystems integrate within a single chip many functions from several domains such as electronics, thermic, biochemistry or microﬂuidics. The modeling of these systems in a single environment and the interface between different domains is very challenging. In this paper, we propose some methods to model the entire system in VHDL-AMS. The models are developed and assembled from elementary building blocks, with a validation through experiments or numerical simulation on a reference tool, toward the complete LOC. For each domain, the modeling methodology is described. The principle is applied to a specific use case: a LOC designed for the detection of micro-pollutants in drinking water. It is based on the ELISA test leading to a pH-shift which is in turn detected by an Ion-Sensitive Field Effect Transistor (ISFET). In the last part of the paper, the ﬁrst results obtained with the complete zero-order model of the LOC are described. Of course, this model has to be improved in order to be faithful to the actual LOC but it will undoubtedly be a major asset for the optimization and reliability improvement of the LOC.