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PEG mediated eco-friendly one pot sunthesis of benzylamine coumarin derivatives using multicomponent reactant

Viradiya D. J., Kotadiya V. C, Khunt M. D., Baria B. H., Bhoya U. C.

International Letters of Chemistry, Physics and Astronomy

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2014

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Vol. 11, iss. 2

177-184

EN

A green resourceful, eco-friendly and facile protocol was developed for the synthesis of benzylamine coumarin derivatives by the reaction of 4-hydroxy coumarin, secondary amine and aromatic aldehyde in the presence of PEG400 as a solvent as well as catalyst at room temperature. A wide range of functional groups were tolerated in the developed protocol. The structures of all the synthesized compounds were confirmed by 1H NMR, IR, MASS and Elemental Analysis. The target molecules were obtained in good to excellent yield applying this method.

2

Novel conversion of 4-aminoquinolines to new tricyclic (R,S)-3-methylazeto[3,2-c] quinolin-2(2aH)-ones and versatile one step synthesis of N-(quinolin-4-yl) carbamates from 4-aminoquinolines

Kotadiya V. C., Viradiya D. J., Baria B. H., Kanzariya J. S., Kakadiya R., Shah A.

International Letters of Chemistry, Physics and Astronomy

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2014

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Vol. 11, iss. 3

265--276

EN

Reaction of 4-aminoquinolines with 4-nitrophenyl chloroformate have resulted in finding a novel transformation of 4-aminoquinolines to tricyclic (R,S)-3-methylazeto[3,2-c]quinolin-2(2aH)-ones. The structure of azeto-quinolinone was determined via spectroscopic and chemical methods. Various alcohols were used as nucleophiles to open the 1-azetinone ring to give the corresponding N-(quinolin-4-yl)carbamates in good yields. We also found a new and versatile one step synthesis of N-(quinolin-4-yl)carbamates by reacting 4-aminoquinolines with alkyl chloroformates in the presence of anhyd K2CO3 in acetonitrile.

3

Highly efficient and eco-friendly one-pot synthesis of penta substitute pyrrole derivatives under catalyst-free conditions

Viradiya D. J., Baria B. H., Kakadiya R., Kotadiya V. C., Shah A.

International Letters of Chemistry, Physics and Astronomy

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2014

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Vol. 11, iss. 3

257--264

EN

An eco-friendly and efficient one-pot synthesis of penta-substituted pyrrole derivatives via a four-component reaction of maldrum’s acid, arylglyoxal monohydrate, dimethyl but-2-yne-dioate and amines under catalyst-free conditions in an environmentally friendly medium is described. The simple experimental procedure, catalyst-free reaction conditions, short period of conversion, and excellent yields are the advantages of the present method. Good chemical yields have been achieved without the need for chromatography and recrystallization or other purification methods.

4

Easy, Simplistic and Green Synthesis of Various Benzimidazole and Benzoxazole Derivatives Using PEG400 as a Green Solvent

Khunt M. D., Kotadiya V. C., Viradiya D. J., Baria B. H., Bhoya U. C.

International Letters of Chemistry, Physics and Astronomy

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2014

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Vol. 6

61--68

EN

An improved environmentally benign procedure for the synthesis of various benzimidazole and benzoxazole derivatives using green solvent PEG400. We have optimized the reaction condition and it was found that PEG400 was believed to be best as compared to PEG200, PEG600 and PEG800 at 80 to 85 °C. This method provides a novel route for the synthesis of benzimidazole and benzoxazole derivatives. The main attractive features of this process are a mild reaction conditions, easy workup procedure and good to excellent yield. The structures of all the synthesized compounds were confirmed by 1H NMR, IR, MASS and Elemental Analysis.